Table 2 Antioxidant defence system and oxidative stress markers in liver tissues of control and carcinogenic male albino rats treated with either pomegranate juice (PJ) or punicalagin (PCG)
Group | Non-carcinogenic groups | Carcinogenic groups | ||||
|---|---|---|---|---|---|---|
Control | PJ (10 mL/ kg b.w) | PCG (18.5 mg/ kg b.w) | HCC (50 mg DENA/ kg b.w) | HCC (50 mg DENA/kg b.w) + PJ(10 mL/ kg b.w) | HCC (50 mg DENA/ kg b.w) + PCG (18.5 mg/ kg b.w) | |
MDA level (μM/mg protein) | 80.44 ± 3.82 | 74.54 ± 3.36 | 92.19 ± 4.06 | 117.76 ± 0.06** | 82.25 ± 5.80## | 74.65 ± 5.68### |
NO level (μmol/ L) | 18.74 ± 1.14 | 19.34 ± 0.81 | 19.86 ± 0.39 | 23.65 ± 0.89*** | 19.19 ± 0.31## | 17.34 ± 0.30### |
GST activity (U/ mg protein) | 8.55 ± 0.51 | 10.83 ± 0.57 | 10.05 ± 1.08 | 12.39 ± 0.92* | 8.25 ± 0.52# | 8.64 ± 1.15# |
SOD activity (U/ mg protein) | 79.79 ± 2.78 | 87.16 ± 4.62 | 75.23 ± 4.59 | 39.95 ± 2.01*** | 68.26 ± 2.77### | 65.21 ± 1.88*### |
CAT activity (U/ mg protein) | 91.04 ± 3.58 | 79.39 ± 4.93 | 75.64 ± 1.52 | 69.19 ± 2.98* | 94.32 ± 4.61## | 75.24 ± 5.94 |