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Fig. 1 | Cancer Cell International

Fig. 1

From: Intracellular and extracellular factors of colorectal cancer liver metastasis: a pivotal perplex to be fully elucidated

Fig. 1

Key molecules and cells for liver-specific metastasis of CRC. Invasive cancer cells from primary CRC tumors invade the adjacent vasculature from the primary site. The invading tumor cells circulate within the blood vessels protected by platelets, extravasate, and finally colonize the liver. The key molecules and cells involved in liver-specific metastasis of CRC include immune cells (MDSCs, TAMs, Kupffer cells), cytokines (IL-6, VEGF-A), chemokines (CXCL13, CXCL1, CXCL12), exosomes (miR-25-3p, miR-130b-3p, miR-425-5p, miR-934, miR-135a-5p, miR581, ANGPTL1) and cell adhesion molecules (L1CAM, E-cadherin, α5β1 Integrin and N-cadherin). Several molecular and cellular interactions have been identified to play critical roles in CRC liver metastasis, and these factors may influence the organ tropism of CRC metastasis

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Cancer Cell International

ISSN: 1475-2867

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