Role of HOXA9 in solid tumors: mechanistic insights and therapeutic potential

Tang, Ling; Peng, Lin; Tan, Chao; Liu, Huai; Chen, Pan; Wang, Hui

doi:10.1186/s12935-022-02767-9

Cancer Cell International

Table 2 Summary of HOXA9 as targets of miRNAs in tumorigenesis and related function

From: Role of HOXA9 in solid tumors: mechanistic insights and therapeutic potential

miRNAs	Tumor type	Target	Functions	PMID	References
miR-1294	Osteosarcoma	HOXA9	miR-1294 functions as a tumor suppressor in OS progression by targeting HOXA9	30575897	[78]
miR-429	Osteosarcoma	HOXA9	miR-429 suppressed OS progression by targeting HOXA9 through Wnt/β-catenin pathway	32782562	[54]
miR-873	Osteosarcoma	HOXA9	miR-873 suppresses the development of OS by directly targeting HOXA9 and inhibiting the Wnt/β-catenin pathway	30816476	[79]
miR-652	Osteosarcoma	HOXA9	miR-652 may negatively regulate HOXA9 expression and inhibit the proliferation, migration, and invasion abilities of osteosarcoma cells through the PI3K/Akt signaling pathway	35111226	[58]
miR-641	Osteosarcoma	HOXA9	miR-641 was found to target the 3' untranslated region of homeobox protein Hox-A9 (HOXA9) and suppressed the expression of HOXA9	30838699	[81]
miR-182	Osteosarcoma	HOXA9	miR-182 downregulates Wnt/β-catenin signaling, inhibits cell proliferation, and promotes apoptosis in osteosarcoma cells by suppressing HOXA9 expression	29254169	[80]
miR-139-5p	Osteosarcoma	HOXA9	miR-139-5p depressed the invasion, proliferation, and EMT of osteosarcoma cells via targeting HOXA9	35800618	[80]
miR-638	Glioma	HOXA9	miR-638 as a tumor suppressor regulates cellular malignancy of gliomas through targeting HOXA9	30536324	[83]
miR-647	Glioma	HOXA9	HOXA9 was validated a direct target of tumor suppressor miR-647	31881106	[84]
miR-182-5p	Non-small cell lung cancer	HOXA9	MiR-182-5p may exert oncogenic influence on NSCLC through regulating target genes such as HOXA9	31906958	[85]
miR-196p	Non-small cell lung cancer	HOXA9	HOXA9 expression is inversely correlated with miR-196b levels in clinical NSCLC samples as compared to that in corresponding control samples	26586336	[41]
miR-19b-3p	Non-small cell lung cancer	HOXA9	High expression of miR-19b-3p was found to be capable of predicting poor clinical prognosis in NSCLC patients	35274735	[86]
miR-633	Colorectal adenocarcinoma	HOXA9	PCED1B-AS1 could negatively regulate the expression of HOXA9 by sponging miR-633	35176937	[87]
miR-381-3p	Human anaplastic thyroid carcinoma	HOXA9	miR-381-3p may function as a tumour suppressor to impede proliferation, migration and invasion and induce apoptosis of DOX-resistant SW1736 and CAL62 cells by inhibiting HOXA9 protein expression	34719830	[88]
miR-638	Breast cancer	HOXA9	miR-638 inhibits breast cancer progression through binding to HOXA9	34416888	[55]
miR-652	Uveal Melanoma	HOXA9	miR-652 as an oncogene promoted HIF-1alpha signaling via repression of HOXA9 in uveal melanoma cells	31740654	[46]
miR-133b	Colorectal cancer	HOXA9	miR-133b targeted the HOXA9/ZEB1 pathway to promote tumor metastasis in CRC cells	28969042	[89]
miR-139-5p	Oral squamous carcinoma	HOXA9	miR-139-5p could directly inhibit HOXA9, which might be a potential mechanism in inhibiting the proliferation, invasiveness and migration of OSCC cells	28780773	[90]

Back to article page

ISSN: 1475-2867

Contact us

General enquiries: journalsubmissions@springernature.com