Table 3 Summary of HOXA9 associated with LncRNAs in human diseases and related function
From: Role of HOXA9 in solid tumors: mechanistic insights and therapeutic potential
LincRNAs | Tumor type | Target | Functions | PMID | References |
|---|---|---|---|---|---|
PEG10 | Cardiac hypertrophy | HOXA9 | PEG10 aggravates cardiac hypertrophy by positively regulating HOXA9 | 31389601 | [100] |
HOTTIP | Prostate Cancer,Pancreatic cancer | HOXA9 | HOTTIP mediated HOXA9 to enhance the Wnt/β-catenin pathway by binding to WDR5 in PCSCs | 28484075; 28947139 | |
MIR503HG | Triple-negative breast cancer | HOXA9 | MIR503HG inhibited cell proliferation and promoted the apoptosis of TNBC cells via the miR-224-5p/HOXA9 axis, which may function as a novel target for the treatment of TNBC | 33869743 | [97] |
ST8SIA6-AS1 | Pituitary adenoma | HOXA9 | ST8SIA6-AS1 targets miR-5195-3p to regulate the expression of HOXA9 and promote the EMT of pituitary adenomas | 35783150 | [96] |
UCA1 | Cardiac hypertrophy | HOXA9 | UCA1 promoted the progression of cardiac hypertrophy through competitively binding with miR-184 to enhance the expression of HOXA9 | 29616999 | [101] |
DLX6-AS1 | Osteosarcoma | HOXA9 | DLX6-AS1 functions as a ceRNA by targeting miR-641/HOXA9 signal pathway to suppress OS cell proliferation and metastasis | 30838699 | [81] |
LINC01140 | Osteosarcoma | HOXA9 | LINC01140 downregulation inhibits the invasion, proliferation, and EMT in osteosarcoma cells through targeting the miR-139-5p/HOXA9 axis | 35800618 | [80] |
PCED1B-AS1 | Colorectal adenocarcinoma | HOXA9 | PCED1B-AS1 could negatively regulate the expression of HOXA9 by sponging miR-633 | 35176937 | [87] |
HOTAIR | Glioma | HOXA9 | HOXA9 as a novel direct regulator of HOTAIR, and establishes HOTAIR as an independent prognostic marker, providing new therapeutic opportunities to treat this highly aggressive cancer | 29644006 | [93] |
KCNQ1OT1 | Laryngeal squamous cell carcinoma | HOXA9 | ALKBH5-mediated m6A modification of KCNQ1OT1 triggers the development of LSCC via upregulation of HOXA9 | 34850551 | [99] |