Fig. 4
From: CHRNB2 represses pancreatic cancer migration and invasion via inhibiting β-catenin pathway
CHRNB2 represses the migration and invasion via ACh-independent mechanisms. A mRNA levels of CHRNB2 in 6 cases of pancreatic cancer with paired normal pancreas and tumor tissue. B CHRNB2 mRNA levels in the tumor tissue of 6 pancreatic cancer patients. 3 cases with LNR = 0, other 3 cases with LNR = 1, examined lymph node > 11. C mRNA levels of CHRNB2 in normal pancreatic ductal epithelial cell line and 6 pancreatic cancer cell lines. D Protein levels of CHRNB2 in 6 pancreatic cancer cell lines. E Efficiency of CHRNB2 knockdown by siRNA in PANC1. F Efficiency of CHRNB2 overexpression by plasmid in T3M4. G, I–L Downregulating CHRNB2 could ACh-independently increase the migration and invasion of PANC1. H, M–P Overexpressing CHRNB2 could ACh-independently decrease the migration and invasion of T3M4. (*: P < 0.05; **: P < 0.01; ***: P < 0.001)