Fig. 6
From: CHRNB2 represses pancreatic cancer migration and invasion via inhibiting β-catenin pathway
CHRNB2 negatively regulated β-catenin pathway. A–D GSEA results showed that CHRNB2 negatively related to the Wnt/β-catenin signaling and downstream MYC and Cyclin D1 pathways, but positively related to the deactivation pathway of β-catenin (NES: Normalized Enrichment Score). E, F Downregulating CHRNB2 could increase the expression of the β-catenin and its downstream proteins including C-Myc, Cyclin D1, and CD44 in both RNA and protein levels. G Overexpressing CHRNB2 could decrease the expression of the β-catenin and its downstream proteins including C-Myc, Cyclin D1, and CD44. H–G The correlation between CHRNB2 and the expression of SOX6, SRY, SOX17 and TCF7L2 in TCGA database. L Overexpressing CHRNB2 could enhance the expression of SOX6, SRY, SOX17, but repress the expression of TCF7L2 in T3M4. (*: P < 0.05; **: P < 0.01; ***: P < 0.001)