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Table 1 Clinical characteristics of the 71 patients evaluated, categorized by IPI scores

From: The prognostic value of IPI in patients with primary breast lymphoma, a multicenter retrospective study

 

Total (n = 71)

IPI 0–1 (n = 45)

IPI 2–5 (n = 26)

P**

Age, years

   

0.592

  < 60

40

34

6

 

  ≥ 60

31

11

20

 

Follow-up duration

    

 Median years (range)

4.7 (0.7–21.8)

4.1 (1.0–21.8)

4.8 (0.7–14.6)

0.025*

Laterality

   

0.614

 Right

42

29

13

 

 Left

23

12

11

 

 Bilateral

6

4

2

 

Nodal site involvement at diagnosis

   

0.348

 None

45

31

14

 

 Axillary ± supraclavicular

26

14

12

 

Presence of B-symptoms

   

NA

 Absent

71

45

26

 

 Present

0

0

0

 

Pathological classification

   

0.513

 DLBCL

57

35

22

 

 Others

14

10

4

 

Pathology

   

0.315

 Non-GCB

29

21

8

 

 GCB

23

14

9

 

 Unknown

5

   

Ann Arbor stage

   

0.342

 IE

39

27

12

 

 IIE

26

14

12

 

 IVE

6

4

2

 

Tumor Size in BUS1

   

0.047

  ≥ 5 cm

7

2

5

 

  < 5 cm

64

43

21

 

LDH

   

0.009

 Normal

34

29

5 11

 

 Elevated

26

12

14

 

 Unknown

11

4

7

 

β2-MG

   

0.541

 Normal

37

25

12

 

 Elevated

17

10

7

 

 Unknown

17

10

7

 

WBC

   

0.855

 Normal

61

37

24

 

 Elevated

3

2

1

 

 Unknown

7

6

1

 

Neut

   

0.622

 Normal

38

24

14

 

 Elevated

25

17

8

 

 Unknown

8

4

4

 

Lymph

   

0.894

 Normal

37

22

15

 

 Elevated

16

10

6

 

 Unknown

18

13

5

 

Ki-67 (%)

   

0.205

  < 50%

11

5

6

 

  ≥ 50%

57

37

20

 

 Unknown

3

3

0

 

BCL-2

   

0.333

 Positive

40

24

16

 

 Negative

25

17

8

 

 Unknown

6

4

2

 

BCL-6

   

0.535

 Positive

34

20

14

 

 Negative

10

7

3

 

 Unknown

27

18

9

 

c-Myc

   

0.990

 Positive

23

17

6

 

 Negative

26

15

11

 

 Unknown

22

13

9

 

Double-hit-lymphomas

   

0.333

 Yes

23

15

8

 

 No

26

17

9

 

 Unknown

22

13

9

 

Triple-hit-lymphomas

    

 Yes

16

8

8

0.217

 No

16

11

5

 

 Unknown

39

26

13

 

P53

   

0.556

 Positive

23

15

8

 

 Negative

23

12

11

 

 Unknown

25

18

7

 

CD30

   

0.936

 Positive

14

9

5

 

 Negative

27

17

10

 

 Unknown

30

19

11

 

CD5

   

0.910

 Positive

19

11

8

 

 Negative

32

19

13

 

 Unknown

20

15

5

 

EBER

   

0.094

 Positive

7

6

1

 

 Negative

51

33

18

 

 Unknown

13

6

7

 

Surgery

   

0.117

 Yes

44

30

14

 

 No

27

15

12

 

Circles of Chemotherapy

   

0.947

  < 4

2

1

1

 

  ≥ 4

51

32

19

 

 Unknown

18

12

6

 

Rituximab Given

   

0.033

 Yes

42

26

16

 

 No

13

4

9

 

 Unknown

16

15

1

 

RT

   

0.618

 Yes

9

7

2

 

 No

17

11

6

 

 Unknown

45

27

18

 

CNS prophylaxis administered

   

0.005

 Yes

6

3

3

 

 No or unknown

65

42

23

 
  1. For bilateral cases, this is the larger value of the left and right breast diameters
  2. BUS breast ultrasound, IPI International Prognostic Index, DLBCL diffuse large B-cell lymphoma, GCB germinal center B-cell like, LDH lactate dehydrogenase, β2-MG β2-microglobulin, WBC white blood cell, Neut neutrophils, Lymph lymphocytes, BCL B-cell lymphoma, CD cluster of differentiation, RT radiotherapy, CNS central nervous system, NA not available
  3. **p indicates a p-value between two groups, “IPI 0–1” and “IPI 2–5”
  4. *Mann–Whitney-U test
  5. Pearson's Chi-square test