Fig. 3
From: Spatial metabolomics on liver cirrhosis to hepatocellular carcinoma progression
The alterations of metabolites’ spatial distributions in sub-regions of HCC sample under positive ionization mode. a HE and MSI images of different sub-regions in HCC including cancer, pseudo lobule (PL), pre-cancer (PC), fibrosis, necrotic tissue (NT), and fatty tissue (FT). b PLS-DA analysis for HCC sub-regions. c Number of metabolites detected from different HCC sub-regions. d Heatmap of significantly differentiated metabolites based on variable importance of projection > 1 (VIP > 1). e KEGG analysis of key altered metabolic pathways between the sub-regions of HCC. f Sample time series analyses of key metabolite expressions in all sub-regions of HCC