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Table 2 Univariate and Multivariate Analysis for overall survival of the Training Cohort

From: Development and validation of a risk prediction model for overall survival in patients with nasopharyngeal carcinoma: a prospective cohort study in China

Characteristic

Univariate

Multivariate

HR (95% CI)

P

HR (95% CI)

P

Age

1.04 (1.03–1.06)

 < 0.001

1.028 (1.014–1.043)

 < 0.001

Gender

    

 Female

1

   

 Male

1.23 (0.875–1.73)

0.234

  

Ethnic

    

 Han

1

   

 Others

1.37 (0.94–2)

0.101

  

Marital status

    

 Married

1

   

 Others

0.845 (0.47–1.52)

0.573

  

Occupation

    

 Worker/clerk

1

   

 Self-employed/unemployed

0.979 (0.62–1.55)

0.929

  

 Professional and technical personnel

2.06 (1.23–3.45)

0.006

  

 Others

1.42 (0.934–2.16)

0.100

  

Stage

    

 I–II

1

 

1

 

 III

2.4 (1.18–4.88)

0.016

2.341 (1.145–4.786)

0.020

 IV

6.56 (3.33–12.9)

 < 0.001

4.593 (2.281–9.248)

 < 0.001

Pathological

    

 Non-keratinizing differentiation

1

 

1

 

 Non-keratinized undifferentiated

1.07 (0.794–1.440)

0.663

1.084 (0.804–1.463)

0.597

 Keratinized and others

2.27 (0.718–7.150)

0.163

3.130 (0.957–10.236)

0.059

Transfer

    

 No

1

   

 Yes

0.97 (0.580–1.620)

0.907

  

Radiotherapy

    

 No

1

 

1

 

 Yes

0.368 (0.268–0.505)

 < 0.001

0.421 (0.268–0.662)

 < 0.001

Chemical therapy

    

 No

1

 

1

 

 Yes

0.469 (0.347–0.634)

 < 0.001

0.895 (0.581–1.380)

0.615

Targeted therapy

    

 No

1

   

 Yes

0.986 (0.699–1.390)

0.938

  

EBV

    

  < 1000

1

 

1

 

  ≥ 1000

3.01 (2.22–4.08)

 < 0.001

1.982 (1.408–2.792)

 < 0.001

BQ

    

  ≤ 0.13

1

   

  > 0.13

0.907 (0.581–1.420)

0.669

  

LAR

    

  ≤ 6.15

1

 

1

 

  > 6.15

4.41 (3.22–6.04)

 < 0.001

2.009 (1.408–2.712)

 < 0.001

NLR

    

  ≤ 4.84

1

 

1

 

  > 4.84

2.61 (1.83–3.71)

 < 0.001

1.521 (1.015–2.278)

0.042

PLR

    

  ≤ 206.33

1

 

1

 

  > 206.33

2.35 (1.73–3.19)

 < 0.001

1.712 (1.202–2.438)

0.003