Fig. 2

TS inhibited the proliferation and invasion of MDA-MB-231 and BT-549 cells and the suppression by CAXII knockout. The relative CAXII expression in MCF-10 A was significantly lower than that of MDA-MB-231 and BT-549, respectively (P < 0.001) (A). Meanwhile its expression was significantly reduced in CAXII-KO group than non-KO and none transfection groups, in tested cells, respectively (P < 0.001) (B). Relative inhibition rates of MDA-MB-231, BT-549 and MCF-10 A treated by different concentrations of TS<SimplePara></SimplePara> were assessed by comparing the NC, respectively (C−E) (P values displayed in Fig. 2 C and 2D were calculated by comparing the inhibition rates of 40 µM TS group and 40 µM TS + CAXII-KO group). The average of cell number was counted by 3 randomly chosen different fields in both cell lines (Magnification 10×) (F–H). Values represent the mean ± SD. NS non-significant, NC negative control