Fig. 7
From: Regulation of mitochondrial complex III activity and assembly by TRAP1 in cancer cells
High complex III expression is associated to resistance to platinum-based therapy in HGSOC. A Expression levels of UQCRC2, TRAP1, TTC19 and CYC1 in HGSOC patients at stage 3, grouped for their pathological response to platinum-based therapy (complete response vs residual disease after completing the therapy). Statistical significance of differences in gene expression levels in responders (n = 366) and non-responders (n = 90) was evaluated by the Mann–Whitney test. B Real-time RT-PCR analysis of indicated genes in platinum-resistant PEA2 and PEO4 compared to their matched-sensitive counterparts PEA1 and PEO1. Data are expressed as mean ± S.E.M. of − ΔΔCt (log2FC) from four independent experiments with technical triplicates each. Numbers indicate the statistical significance (p value), based on Student’s t-test (significant values highlighted in red)