Fig. 1

Transcriptomic landscape of childhood ALL. A Pie chart showing the number of significantly (adjusted p-value < 0.05) upregulated and downregulated genes between T-ALL and T naïve cells (upper panel) and B-ALL and B naïve cells (lower panel). The charts indicate the number of protein coding and lncRNAs differentially regulated. B Number of common lncRNAs between the lncRNAs upregulated in T-ALL vs T naïve cells and the lncRNAs upregulated in B-ALL vs B naïve cells. Fisher’s exact test confirmed the overlapping to be not significant with a p-value = 0.088. C PCA of the global lncRNA panorama of all the samples included in differential expression analysis