Fig. 4

LncRNA landscape in paediatric ALL and AML. A PCA of the lncRNA landscape of childhood B-ALL, T-ALL and AML RNA-seq samples from Paediatric Cancer Genome Project by Saint Jude Children’s Research Hospital. B Hierarchical clustering output shows lncRNA expression in paediatric B-ALL, T-ALL and AML. Expression values, normalized by row, are indicated with a red to blue graded color. Each cluster comprises the main group of lncRNAs sharing a similar expression profile across the various diseases considered. C Volcano plot illustrating the transcriptome variations between AML and T-ALL. Significance and fold change threshold are reported as in Fig. 2B. Grey dots mark the position of the lncRNAs highlighted in Fig. 2C. D Volcano plot showing the transcriptomic differences between AML and B-ALL. Significance and fold change threshold are reported as in Fig. 2B. Grey dots mark the position of the lncRNAs highlighted in Fig. 2B