Fig. 2

Establishment of an E2F-related RFS predictive gene signature using LASSO Cox regression in the MSKCC cohort. LASSO Cox regression identified four E2F-related genes, CDKN2C, CDKN3, RACGAP1, and RRM2, and the E2F-related gene signature was established based on these four genes (A, B). Based on the median expression levels of CDKN2C, CDKN3, RACGAP1, and RRM2, PCa patients were divided into high and low groups, and PCa patients with high expression levels of these four genes exhibited poorer recurrence-free survival time validated by log-rank survival test (C–F)