Table 3 The potential role of exo-circRNAs as biomarkers in the diagnosis and treatment of lung cancer
From: Exosomal circular RNA: a signature for lung cancer progression
CircRNA | Role/Function | Regulation | Mechanism | Sample | Refs |
|---|---|---|---|---|---|
Circ_0047921 | Biomarker | ↑ | – | Serum Exosome | [204] |
Circ_005628 | Biomarker | ↑ | Circ_005628/miR-1244/TRIM44 | Serum Exosome | [205] |
circ_0001492 circ_0001346 circ_0000690 | Biomarker | ↑ | circ_0001492/miR-93-5p | Plasma Exosome | [206] |
Circ_0001439 | Biomarker | ↑ | – | Plasma Exosome | [207] |
CircFARSA | Biomarker/ enhances NSCLC metastasis | ↑ | CircFARSA/PTEN/PI3K/AKT axis | Cell Line Exosome | [116] |
hsa_circ_0069313 | Biomarker | ↑ | – | Serum Exosome | [208] |
Circ_0043278 | Increased expression of ROCK1, CDKN1B, and AKT3 promotes proliferation, invasion, and migration | ↑ | miR-520f /ROCK1/CDKN1B/AKT3 axis | Cell Line Exosome | [209] |
Circ CDYL | Sponges miR-185-5p and controls TNRC6A to suppress cell growth and trigger cell death | ↓ | Circ CDYL/miR-185-5p/TNRC6A axis | Cell Line Exosome | [210] |
CircARHGAP10 | Boost cell division, migration, invasion, and glucose metabolism | ↑ | CircARHGAP10/miR-638/FAM83F axis | Serum Exosome | [211] |
hsa_circ_0002130 | Involves facilitating resistance to osimertinib | ↑ | Hsa_circ_0002130/miR-498 axis | Serum Exosome | [192] |
Circ_0008928 | Upregulation of miR-488 and HK2 in CDDP-resistant LC promotes cell proliferation, migration, and glycolysis metabolism | ↑ | Circ_0008928/miR-488/HK2 axis | Serum Exosome | [212] |
CircSETDB1 | Promotes growth and metastasis | ↑ | CircSETDB1/miR-7/Sp1 axis | Cell Line Exosome | [213] |
circRNA-002178 | Immune escape | ↑ | CircRNA-002178/miR-34/PDL1 | Plasma Exosome | [168] |
Circ_0076305 | DDP resistance in NSCLC is controlled by upregulating ABCC1 expression via miR-186-5p sponging | ↑ | Circ_0076305/miR-186-5p/ABCC1 axis | Cell Line Exosome | [214] |
CircVMP1 | miR-524-5p-METTL3/SOX2 axis targeting promotes NSCLC development and DDP resistance | ↑ | miR-524-5p-METTL3/SOX2 axis | Cell Line Exosome | [104] |