Fig. 2
From: Role of microRNA-34b-5p in cancer and injury: how does it work?
Mechanism of miR-34b-5p in the development of cancer. A Role of miR-34b-5p in lung cancer: High levels of miR-34b-5p in the lungs inhibited Cdkn1 of p53, Then the appearance of p21 protein, cyclin and CDK complex caused the decrease in RB protein phosphorylation, thereby inhibiting the expression of E2F and cyclin A and E; CNA downregulation led to the cell cycle arrest. B Role of miR-34b-5p in renal cancer: The expression of miR-34b-5p was upregulated, which decreased the level of IGF1R. Also, the PI3K/Akt signal transduction pathway was inhibited, thereby reducing the proliferation, invasion, and metastasis of renal cancer cells. C Role of miR-34b-5p in thyroid carcinoma: MiR-34b-5p could influence angiogenesis in thyroid carcinoma by changing endothelial cell proliferation through reduced VEGF-A level, arrest cell cycle and induce apoptosis. D Role of miR-34b-5p in diffuse large B-cell lymphoma: Nuclear paraspeckle assembly transcript (NEAT)1 inhibited cell proliferation and promoted cell apoptosis through decreasing miR‑34b‑5p level and upregulating GLI1