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Fig. 7 | Cancer Cell International

Fig. 7

From: Glioblastoma cells have increased capacity to repair radiation-induced DNA damage after migration to the olfactory bulb

Fig. 7

Neuron–tumor cell contact. A Representative matched images of NSC11 and NSC20 tumor cells (Nestin+) and MAP2+ neurons, TH+ neurons and GABA+ neurons in the OB and RH (×40 magnification—orthogonal projection from confocal images, DAPI, Nestin and protein of interest are represented in blue, green and red, respectively). B %NSC11 and NSC20 cells in contact with each neuron type. Each point corresponds to an individual mouse with at least 100 cells analyzed in each location with lines connecting the matched OB (white circle) and RH (black circle) from the same mouse. C Representative zoomed-in images illustrating contact points (white arrows) between NSC11 tumor cells (Nestin+) and MAP2+ neurons, TH+ neurons and GABA+ neurons in the OB. D %tumor cells (Nestin+) versus the number of contacts MAP2+ neurons, TH+ neurons and GABA+ neurons. Each point corresponds to an individual mouse with at least 100 cells analyzed in each location with lines connecting the matched OB (white circle) and RH (black circle) from the same mouse. *p-val < 0.05

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Cancer Cell International

ISSN: 1475-2867

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