CD5L-associated gene analyses highlight the dysregulations, prognostic effects, immune associations, and drug-sensitivity predicative potentials of LCAT and CDC20 in hepatocellular carcinoma

Zhang, Xiuzhi; Liu, Xiaoli; Zhu, Keke; Zhang, Xue; Li, Ningning; Sun, Tao; Fan, Shasha; Dai, Liping; Zhang, Jinzhong

doi:10.1186/s12935-022-02820-7

Table 2 The correlations of CD5L, LCAT and CDC20 with anti-cancer drug sensitivities in HCC cell lines

From: CD5L-associated gene analyses highlight the dysregulations, prognostic effects, immune associations, and drug-sensitivity predicative potentials of LCAT and CDC20 in hepatocellular carcinoma

	Drugs	Putative target	Pathway name	R	P value
CD5L	Mitoxantrone		DNA replication	−0.811	0.002^**
	OTX015	BRD2, BRD3, BRD4	Chromatin other	−0.642	0.033^*
	I-BRD9	BRD9	Chromatin other	−0.621	0.041^*
	Fulvestrant	ESR	Hormone-related	0.642	0.033^*
LCAT	IGF1R_3801	IGFR1	IGF1R signaling	−0.755	0.010^*
	WZ4003	NUAK1, NUAK2	Other, kinases	−0.691	0.023^*
	Niraparib	PARP1, PARP2	Genome integrity	−0.682	0.025^*
	NVP-ADW742	IGF1R	IGF1R signaling	−0.645	0.037^*
	AZD5582	XIAP, cIAP	Apoptosis regulation	−0.627	0.044^*
	Alpelisib	PI3Kalpha	PI3K/MTOR signaling	−0.618	0.048^*
	Sorafenib	PDGFR, KIT, VEGFR, RAF	Other, kinases	0.636	0.040^*
	Dabrafenib	BRAF	ERK MAPK signaling	0.736	0.013^*
	AZD4547	FGFR1, FGFR2, FGFR3	RTK signaling	0.755	0.010^*
	P22077	USP7, USP47	Protein stability and degradation	0.800	0.005^**
	Acetalax		Unclassified	0.809	0.004^**
CDC20	Picolinici-acid	Inflammatory related	Other	−0.873	0.001^**
	Vincristine		Mitosis	−0.818	0.004^**
	Niraparib	PARP1, PARP2	Genome integrity	−0.745	0.012^*
	Palbociclib	CDK4, CDK6	Cell cycle	−0.727	0.015^*
	Carmustine		DNA replication	−0.727	0.015^*
	PRIMA-1MET	TP53 activation	p53 pathway	−0.718	0.017^*
	Fludarabine		Unclassified	−0.709	0.019^*
	CZC24832	PI3Kgamma	PI3K/MTOR signaling	−0.700	0.021^*
	AZD5363	AKT1, AKT2, AKT3, ROCK2	Other, kinases	−0.682	0.025^*
	Docetaxel	Microtubule stabiliser	Mitosis	−0.682	0.025^*
	CDK9_5038	CDK9	Cell cycle	−0.673	0.028^*
	Mitoxantrone		DNA replication	−0.673	0.028^*
	Vinblastine	Microtubule destabiliser	Mitosis	−0.664	0.031^*
	Vinorelbine	Microtubule destabiliser	Mitosis	−0.645	0.037^*
	JAK_8517	JAK1, JAK2	Other, kinases	−0.636	0.040^*
	Dinaciclib	CDK1, CDK2, CDK5, CDK9	Cell cycle	−0.627	0.044^*
	Podophyllotoxin bromide		Unclassified	−0.627	0.044^*
	Dactinomycin		Other	−0.627	0.044^*

^*p < 0.05; ^**p < 0.01. The correlations of the gene expressions with log-transformed half maximal inhibitory concentrations (LN_IC50s) of the drugs in the HCC cell lines were estimated. Spearman correlation analysis was used and p < 0.05 was considered significant

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