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Fig. 2 | Cancer Cell International

Fig. 2

From: The various role of microRNAs in breast cancer angiogenesis, with a special focus on novel miRNA-based delivery strategies

Fig. 2

MicroRNA biogenesis RNA polymerase II transcribes intergenic microRNA genes into locally hairpin formations called the primary microRNAs (pri-miRNAs), that are then properly processed to precursor microRNA (pre-microRNA) via Drosha and Pasha in the nucleus. Owing to Dicer activity in conjunction with additional cofactors, a 22 nt duplex is produced after exporting in the cytoplasm. MicroRNAs that have been mature recognize seed sequences in the 3′ UTRs of target mRNAs and regulate gene expression by interrupting or inhibiting target mRNA translation

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Cancer Cell International

ISSN: 1475-2867

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