Fig. 2

A. The expression of genes encoding proteins of ccRCC secretome is altered in ccRCC tumors. A The plots show results of qPCR analysis performed in non-neoplastic kidney samples (N) and ccRCC tumor samples (T). All: analysis performed in all samples, without differentiation into TNM Stage/Fuhrman grade. N: n = 92; T: n = 92; TNM stage: tumor samples were classified into Stage 1 (N1: n = 49, T1: n = 49), Stage 2 (N2: n = 12, T2: n = 12), Stage 3 (N3: n = 27, T3: n = 27), Stage 4: N4: n = 4, T4: n = 4). Fuhrman grade: tumor samples were classified into Grade 1 (N1: n = 27, G1: n = 27), Grade 2 (N1: n = 51, G2: n = 51), Grade 3 (N3: n = 9, G3: n = 8), Grade 4 (N4: n = 1, G4: n = 1). Statistical analysis was performed using Wilcoxon matched-pairs signed rank test or paired t test, depending on data normality distribution. B The plots show results of UALCAN/CPTAC analysis on proteomic data from ccRCC tumors (n = 110) and normal kidney tissues (n = 84)