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Fig. 6 | Cancer Cell International

Fig. 6

From: Heat shock protein 27 deficiency promotes ferrous ion absorption and enhances acyl-Coenzyme A synthetase long-chain family member 4 stability to promote glioblastoma cell ferroptosis

Fig. 6

Knockdown of HSP27 inhibits tumor growth in vivo. A Fluorescent images of intracranial tumor size in mice on days 7, 14, and 28 in the control and experimental groups. B Quantitative analysis of fluorescence images. C Mouse survival curves of control and experimental groups, n = 6. D H&E slice of mouse intracranial tumor, scale bar = 100 μm. E IHC image of anti-HSP27, Ki67 and ACSL4 tumor slices, scale = 100 μm. F, G Comparison of Fe2 + and MDA levels of xenograft samples in the control and experimental groups. H Schematic of HSP27 inducing ferroptosis in GBM. Student’s t-test for two-group comparisons: *p < 0.05, **p < 0.01, ***p < 0.001; log-rank test: p < 0.05

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Cancer Cell International

ISSN: 1475-2867

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