Table 1 Selected lncRNAs involved in glycolysis of gynecologic cancers
From: Long noncoding RNAs: glycolysis regulators in gynaecologic cancers
Mechanism | LncRNAs | Molecules and signaling pathways involved | Expression | Phenotypes affected | Cancer | Refs. |
|---|---|---|---|---|---|---|
ceRNA | HOXB-AS3 | HOXB-AS3/miR-378a-3p/LDHA axis | Up | Proliferation ( +) Migration ( +) Invasion ( +) | OC | [132] |
|  | LINC00504 | LINC00504/miR-1244/PKM2, HK2, PDK1 axis | Up | Proliferation ( +) Apoptosis (-) | OC | [136] |
|  | SNHG16 | TFAP2A/SNHG16/miR-490-3p/HK2 axis | Up | Proliferation ( +) | EC | [152] |
|  | DLEU2 | (1) DLEU2/miR-455/HK2 axis (2) EZH2/DLEU2/miR-181a/HK2 axis | Up | EMT ( +) | EC | [155] |
|  | H19 | H19/miR-324-5p/PKM2 axis | Up | Apoptosis (−) Proliferation ( +) Migration ( +) Invasion ( +) | OC | [146] |
|  | NEAT1 | NEAT1/miR-34a-5p/LDHA axis | Up | 5-Fu resistance ( +) Proliferation ( +) Migration ( +) | CC | [158] |
|  | TDRG1 | TDRG1/miR-214-5p/SEMA4C axis | Up | Invasion ( +) Proliferation ( +) | CC | [163] |
|  | XLOC_006390 | XLOC_006390/miR-338-3p, miR-331-3p/PKM2 axis | Up | Migration ( +) Invasion ( +) Apoptosis (−) Metastasis ( +) | CC | [165] |
|  | OIP5-AS1 | miR-124-5p/IDH2/HIF-1α pathway | Up | Proliferation ( +) | CC | [168] |
|  | UCA1 | UCA1/miR-493-5p/HK2 | Up | Proliferation ( +) | CC | [182] |
|  | LINC00662 | LINC00662/miR-375/HIF-1α axis | Up | Proliferation ( +) | OC | [172] |
Signal | UCA1 | UCA1/HK2 pathway | Up | Radio-resistance ( +) | CC | [183] |
|  | CTSLP8 | CTSLP8/PKM2 pathway | Up | Proliferation ( +) DDP resistance ( +) | OC | [177] |
|  | LINC00092 | CXCL14/LINC00092/PFKFB2 reciprocal feedback loop | Up | Migration ( +) Invasion ( +) | OC | [175] |
Guide | EPB41L4A-AS1 | (1) recruit HDAC2 into the VHL inducing HIF-1αaccumulation (2) EPB41L4A-AS1/TIGA1/VDAC1/HIF-1α pathway | Down | Proliferation (−) Apoptosis ( +) Migration (−) Invasion (−) Cisplatin-resistance (−) | CC | [184] |
|  | LINC00035 | recruit CEBPB into the SLC16A3 promoter region, increasing the SLC16A3 transcription | Up | Viability ( +) Apoptosis (−) Migration ( +) Invasion ( +) | OC | [190] |
Scaffold | NRCP | as a Scaffold between STAT1 and RNA polymerase II, leading to increased expression of GPI, ALDOA, and ALDOC | Up | Proliferation ( +) Apoptosis (−) | OC | [192] |
Decoy | GHET1 | GHET1/HIF-1αpathway | Up | Proliferation ( +) | OC | [195] |