Fig. 1

Assessment of PCC glucose transport and lactate release. A Time-dependent glucose transport in PCCs at baseline. B-C PCCs pre-incubated for 72 h with SFM or three different PSC-CMs (PSC-1, PSC-2, and HPaSteC) were investigated for B glucose transport at 4 h and C extracellular lactate at 24 h and 48 h. For C, cells were maintained in low-glucose SFM during lactate release assessment. Data presented as mean ± SEM of 3–4 replicates. For A *p < 0.05, **p < 0.01 comparing 2 h, 4 h, and 8 h with 1 h. For C *p < 0.05, **p < 0.01 comparing SFM with PSC-CM at 24 h or 48 h, and ^#p < 0.05, ^##p < 0.01 comparing 24 h with 48 h in both SFM and PSC-CM. PCC pancreatic cancer cell, PSC-CM pancreatic stellate cell-conditioned medium, SFM serum-free DMEM