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Fig. 8 | Cancer Cell International

Fig. 8

From: Pancreatic stellate cell-induced gemcitabine resistance in pancreatic cancer is associated with LDHA- and MCT4-mediated enhanced glycolysis

Fig. 8

Impact of PSCs on glycolysis and GEM sensitivity in PCCs. PSC-secreted factors promote glycolysis and induce loss of GEM sensitivity through increased ERK phosphorylation. Glycolysis in PCCs is mediated by increased expression of LDHA and MCT4. Exposure to inhibitors of glycolysis (NV-5440) or MEK/ERK (PD98059) showed protection of PCCs from both PSC-induced loss of GEM sensitivity and enhanced glycolysis as indicated by the increased secretion of lactate. GEM gemcitabine, LDHA lactate dehydrogenase A, MCT4 monocarboxylate transporter 4, PCCs pancreatic cancer cells, PKM2 pyruvate kinase M2, PSCs pancreatic stellate cells

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Cancer Cell International

ISSN: 1475-2867

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