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Fig. 1 | Cancer Cell International

Fig. 1

From: In vitro co-culture systems of hepatic and intestinal cells for cellular pharmacokinetic and pharmacodynamic studies of capecitabine against colorectal cancer

Fig. 1

CAP exhibited little inhibitory effect on CRC cells under the condition of inactivation by the liver. a The structure of CAP and metabolic conversion of CAP to 5-FU. b Relative cell viability of CRC cells measured by CCK-8 assay after treated with CAP at dose ranges from 10 to 1000 μM for 48 h. c–g Cell apoptosis of CRC cells detected by flow cytometric analysis after treatment with 500 μM of CAP for 24 or 48 h. Data were expressed as the mean ± SD (n = 3) of three parallel experiments. *P < 0.05, **P < 0.01 vs control

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Cancer Cell International

ISSN: 1475-2867

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