Fig. 6

Intracellular concentrations of CAP, 5′-DFCR, 5′-DFUR, 5-FU, FUTP, FdUTP and FdUMP in CRC cells under co-cultured with HepG2 cells or not. a Metabolic pathway of 5-FU. b–f Intracellular concentrations of CAP, 5′-DFCR, 5′-DFUR, 5-FU, FUTP, FdUTP and FdUMP under co-culture or not. Each point represents mean ± SD (n = 6). ^*P < 0.05, ^**P < 0.01 vs the group without co-culture