Fig. 7
Correlation analysis between pharmacokinetics and relative inhibition among CRC cells. Correlation analysis was conducted between Cmax (a–d) or AUC0-t (e–h) of CAP, 5′-DFCR, 5′-DFUR or 5-FU and the relative inhibition among CRC cells under pre-metabolized by HepG2 cells, respectively. Correlation analysis was conducted between intracellular concentrations of CAP, 5′-DFCR, 5′-DFUR or 5-FU (i–l) or relative concentrations of FUTP, FdUTP or FdUMP (m–o) and the relative inhibition among CRC cells under co-cultured with HepG2 cells, respectively