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Table 2 Demographic and clinical characteristics of patients with EC. (n = 508)

From: Clinical usefulness of the lymphocyte-to-monocyte ratio and aggregate index of systemic inflammation in patients with esophageal cancer: a retrospective cohort study

Variables

Validation cohort [cases (%)]

Training cohort

[cases (%)]

Whole population [cases (%)]

χ2

P value

Age (y)

   

0.004

0.950

  < 65

85 (55.9)

198 (55.6)

283 (55.7)

  

  ≥ 65

67 (44.1)

158 (44.4)

225 (44.3)

  

Sex

   

0.317

0.574

 Female

53 (34.9)

115 (32.3)

168 (33.1)

  

 Male

99 (65.1)

241 (67.7)

340 (66.9)

  

Neoadjuvant therapy

   

0.745

0.388

 Yes

112 (73.7)

275 (77.2)

387 (76.2)

  

 No

40 (26.3)

81 (22.8)

121 (23.8)

  

Comorbidities

   

2.021

0.155

 No

97 (63.8)

250 (70.2)

347 (68.3)

  

 Yes

55 (36.2)

106 (29.8)

161 (31.7)

  

Treatment methods

   

3.741

0.154

 Combination therapy

18 (11.8)

47 (13.2)

65 (12.8)

  

 Chemotherapy

88 (57.9)

230 (64.6)

318 (62.6)

  

 NC

46 (30.3)

79 (22.2)

125 (24.6)

  

Histologic subtypes

   

0.029

0.865

 ESCC

142 (93.4)

334 (93.8)

476 (93.7)

  

 Others

10 (6.6)

22 (6.2)

32 (6.3)

  

Histological grade

   

1.179

0.555

 III

32 (21.1)

67 (18.8)

99 (19.5)

  

 II

77 (50.7)

199 (55.9)

276 (54.3)

  

 I

43 (28.3)

90 (25.3)

133 (26.2)

  

T stage

   

3.101

0.078

 Tis + T1 + T2

94 (61.8)

190 (53.4)

284 (55.9)

  

 T3 + T4

58 (38.2)

166 (46.6)

224 (44.1)

  

N stage

   

0.080

0.777

 N0 + N1

127 (83.6)

301 (84.6)

428 (84.3)

  

 N2 + N3

25 (16.4)

55 (15.4)

80 (15.7)

  

M stage

   

0.509

0.476

 M0

151 (99.3)

351 (98.6)

502 (98.8)

  

 M1

1 (0.7)

5 (1.4)

6 (1.2)

  

TNM stage

   

0.140

0.708

 0 + I + II

86 (56.6)

195 (54.8)

281 (55.3)

  

 III + IV

66 (43.4)

161 (45.2)

227 (44.7)

  

Tumor location

   

0.007

0.997

 Upper

27 (17.8)

63 (17.7)

90 (17.7)

  

 Middle

53 (34.9)

123 (34.6)

176 (34.6)

  

 Lower

72 (47.4)

170 (47.8)

242 (47.6)

  

Vascular invasion

   

0.342

0.559

 No

112 (73.7)

271 (76.1)

383 (75.4)

  

 Yes

40 (26.3)

85 (23.9)

125 (24.6)

  

Nerve invasion

   

2.127

0.145

 No

119 (78.3)

298 (83.7)

417 (82.1)

  

 Yes

33 (21.7)

58 (16.3)

91 (17.9)

  

Tumor size (cm)

   

0.318

0.573

  < 3

66 (43.4)

145 (40.7)

211 (41.5)

  

  ≥ 3

86 (56.6)

211 (59.3)

297 (58.5)

  

NLR

   

0.364

0.546

  < 1.685

69 (45.4)

172 (48.3)

241 (47.4)

  

  ≥ 1.685

83 (54.6)

184 (51.7)

267 (52.6)

  

PLR

   

0.399

0.527

  < 83.590

62 (40.8)

156 (43.8)

218 (42.9)

  

  ≥ 83.590

90 (59.2)

200 (56.2)

290 (57.1)

  

NMR

   

1.588

0.208

  < 6.959

61 (40.1)

122 (34.3)

183 (36.0)

  

  ≥ 6.959

91 (59.9)

234 (65.7)

325 (64.0)

  

LMR

   

1.367

0.242

  < 4.724

88 (57.9)

186 (52.2)

274 (53.9)

  

  ≥ 4.724

64 (42.1)

170 (47.8)

234 (46.1)

  

SII

   

0.276

0.599

  < 334.165

70 (46.1)

173 (48.6)

243 (47.8)

  

  ≥ 334.165

82 (53.9)

183 (51.4)

265 (52.2)

  

NLPR

   

0.521

0.470

  < 0.006

50 (32.9)

129 (36.2)

179 (35.2)

  

  ≥ 0.006

102 (67.1)

227 (63.8)

329 (64.8)

  

SIRI

   

0.437

0.508

  < 0.901

69 (45.4)

173 (48.6)

242 (47.6)

  

  ≥ 0.901

83 (54.6)

183 (51.4)

266 (52.4)

  

AISI

   

0.317

0.573

  < 178.055

71 (46.7)

176 (49.4)

247 (48.6)

  

  ≥ 178.055

81 (53.3)

180 (50.6)

261 (51.4)

  

RDW (%)

   

0.238

0.626

  < 13.350

69 (45.4)

170 (47.8)

239 (47.0)

  

  ≥ 13.350

83 (54.6)

186 (52.2)

269 (53.0)

  

Hb (g/L)

   

0.023

0.880

  < 126.500

63 (41.4)

145 (40.7)

208 (40.9)

  

  ≥ 126.500

89 (58.6)

211 (59.3)

300 (59.1)

  

WBC (× 109/L)

   

0.223

0.637

  < 6.305

94 (61.8)

228 (64.0)

332 (63.4)

  

  ≥ 6.305

58 (38.2)

128 (36.0)

186 (36.6)

  

Neut (× 109/L)

   

0.013

0.911

  < 3.205

67 (44.1)

155 (43.5)

222 (43.7)

  

  ≥ 3.205

85 (55.9)

201 (56.5)

286 (56.3)

  

Mono (× 109/L)

   

0.209

0.648

  < 0.405

62 (40.8)

153 (43.0)

215 (42.3)

  

  ≥ 0.405

90 (59.2)

203 (57.0)

293 (57.7)

  

ALB (g/L)

   

0.083

0.773

  < 42.150

79 (52.0)

190 (53.4)

269 (53.0)

  

  ≥ 42.150

73 (48.0)

166 (46.6)

239 (47.0)

  

PA (mg/L)

   

1.762

0.184

  < 208.500

62 (40.8)

168 (47.2)

230 (45.3)

  

  ≥ 208.500

90 (59.2)

188 (52.8)

278 (54.7)

  

LDL (mmol/L)

   

0.951

0.330

  < 2.535

65 (42.8)

169 (47.5)

234 (46.1)

  

  ≥ 2.535

87 (57.2)

187 (52.5)

274 (53.9)

  

CRP (mg/L)

   

3.257

0.071

  < 3.655

64 (42.1)

181 (50.8)

245 (48.2)

  

 ≥ 3.655

88 (57.9)

175 (49.2)

263 (51.8)

  
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Cancer Cell International

ISSN: 1475-2867

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