Clinical usefulness of the lymphocyte-to-monocyte ratio and aggregate index of systemic inflammation in patients with esophageal cancer: a retrospective cohort study

Table 3 Univariate and multivariate Cox analyses on variables for the prediction of OS of EC patients

Variables	Univariate analysis			Multivariate analysis
Variables	HR	95% CI	P value	HR	95% CI	P value
High LMR	0.103	0.079–0.134	< 0.001	0.483	0.252–0.925	0.028
High NLPR	3.650	2.858–4.661	< 0.001	1.262	0.859–1.854	0.236
High SIRI	12.500	9.509–16.608	< 0.001	1.313	0.394–4.381	0.658
High AISI	21.739	15.704–30.631	< 0.001	4.099	1.127–14.902	0.032
High ALB	0.205	0.162–0.261	< 0.001	0.675	0.454–1.005	0.053
High CRP	2.639	2.095–3.320	< 0.001	1.215	0.938–1.575	0.140
High LDL	5.000	3.920–6.366	< 0.001	1.488	1.017–2.176	0.040
High PA	3.165	2.514–3.985	< 0.001	1.549	1.154–2.080	0.004
High RDW	7.463	5.795–9.592	< 0.001	2.213	1.374–3.565	0.001
Lack of treatment	1.425	1.165–1.744	0.001	1.322	1.062–1.645	0.012
Lower esophagus	1.248	1.076–1.449	0.004	1.215	1.035–1.427	0.017
Presence of vascular invasion	2.183	1.688–2.825	< 0.001	1.421	1.065–1.895	0.017
Receive of neoadjuvant therapy	1.887	1.458–2.440	< 0.001	1.363	1.038–1.789	0.026
Presence of nerve invasion	2.331	1.739–3.121	< 0.001	1.539	1.109–2.136	0.010

ISSN: 1475-2867