Table 4 The Predictive Performance (C-Index, NRI and IDI) of Different Models for Predicting EC patients’ OS and PFS in the Training Cohort and Validation Cohort
Model | Author | Key Predictors of the Model | Index | Outcome | Training cohort | Validation cohort | ||||
|---|---|---|---|---|---|---|---|---|---|---|
Estimate | 95% CI | P value | Estimate | 95% CI | P value | |||||
Model proposed in this study | Huike Wang et al. 2022 | A nomogram model including nerve invasion, vascular invasion, neoadjuvant therapy, tumor location, treatment methods, RDW, PA, LDL, AISI and LMR | C-index | OS | 0.798 | 0.782 to 0.814 | – | 0.790 | 0.763 to 0.817 | – |
PFS | 0.754 | 0.717 to 0.791 | – | 0.702 | 0.677 to 0.727 | – | ||||
Model A[38] | Xiang Lv et al. 2021 | A nomogram model including age, TNM stage, T stage, N stage, LMR and NLR | C-index | OS | 0.759 | 0.741 to 0.777 | – | 0.769 | 0.744 to 0.794 | – |
PFS | 0.704 | 0.663 to 0.745 | – | 0.619 | 0.542 to 0.695 | – | ||||
NRI | 1-year OS | − 0.081 | − 0.408 to − 0.137 | – | − 0.102 | − 0.625 to 0.159 | – | |||
3-year OS | − 0.180 | − 0.563 to − 0.009 | – | − 0.195 | − 0.581 to 0.234 | – | ||||
5-year OS | − 0.211 | − 0.371 to 0.000 | – | − 5.882 | − 0.398 to − 0.316 | – | ||||
1-year PFS | − 0.186 | − 0.306 to − 0.263 | – | − 0.077 | − 0.364 to − 0.246 | – | ||||
3-year PFS | − 0.240 | − 0.482 to − 0.049 | – | − 0.127 | − 0.504 to 0.035 | – | ||||
5-year PFS | − 0.283 | − 0.435 to − 0.089 | – | − 0.305 | − 0.516 to − 0.007 | – | ||||
IDI | 1-year OS | − 0.046 | − 0.104 to − 0.011 | 0.020 | − 0.066 | − 0.169 to 0.003 | 0.070 | |||
3-year OS | − 0.054 | − 0.096 to − 0.021 |  < 0.001 | − 0.023 | − 0.130 to − 0.036 | 0.338 | ||||
5-year OS | − 0.055 | − 0.103 to − 0.016 |  < 0.001 | − 0.023 | − 0.128 to 0.046 | 0.448 | ||||
1-year PFS | − 0.039 | − 0.120 to − 0.027 | 0.289 | − 0.041 | − 0.161 to − 0.048 | 0.338 | ||||
3-year PFS | − 0.117 | − 0.187 to − 0.036 |  < 0.001 | − 0.100 | − 0.229 to − 0.010 | 0.030 | ||||
5-year PFS | − 0.148 | − 0.243 to − 0.061 |  < 0.001 | − 0.172 | − 0.297 to − 0.022 | 0.030 | ||||
The AJCC staging system |  | T stage, N stage and M stage | C-index | OS | 0.542 | 0.511 to 0.573 | – | 0.544 | 0.519 to 0.569 | – |
PFS | 0.609 | 0.593 to 0.625 | – | 0.542 | 0.517 to 0.567 | – | ||||
NRI | 1-year OS | − 0.417 | − 0.575 to − 0.230 | – | − 0.590 | − 0.963 to − 0.297 | – | |||
3-year OS | − 0.671 | − 0.778 to − 0.567 | – | − 0.694 | − 0.878 to − 0.508 | – | ||||
5-year OS | − 0.211 | − 0.371 to 0.000 | – | − 0.311 | − 0.666 to − 0.050 | – | ||||
1-year PFS | − 0.297 | − 0.531 to − 0.062 | – | − 0.469 | − 0.797 to − 0.011 | – | ||||
3-year PFS | -0.497 | − 0.902 to − 0.345 | – | − 0.449 | − 0.895 to − 0.110 | – | ||||
5-year PFS | -0.343 | − 0.755 to − 0.211 | – | − 0.369 | − 1.160 to − 0.185 | – | ||||
IDI | 1-year OS | − 0.173 | − 0.247 to − 0.088 |  < 0.001 | − 0.196 | − 0.307 to − 0.126 |  < 0.001 | |||
3-year OS | − 0.535 | − 0.611 to − 0.448 |  < 0.001 | − 0.788 | − 0.868 to − 0.822 |  < 0.001 | ||||
5-year OS | − 0.314 | − 0.375 to − 0.268 |  < 0.001 | − 0.368 | − 0.509 to − 0.265 |  < 0.001 | ||||
1-year PFS | − 0.136 | − 0.220 to − 0.074 |  < 0.001 | − 0.123 | − 0.275 to − 0.035 |  < 0.001 | ||||
3-year PFS | − 0.348 | − 0.437 to − 0.250 |  < 0.001 | − 0.252 | − 0.420 to − 0.123 |  < 0.001 | ||||
5-year PFS | − 0.349 | − 0.431 to − 0.254 |  < 0.001 | − 0.342 | − 0.504 to − 0.172 | 0.010 | ||||