Table 3 Potential lncRNAs and miRNAs biomarkers in ccRCC
Samples | NcRNAs | Sensitivity (%) | Specificity (%) | Refs. | |
|---|---|---|---|---|---|
Tissue | LncRNA | APOC1P1 | 73.3 | 93.3 | [149] |
OTUD6B-AS1 | 77.3 | 81.4 | [139] | ||
ZNF180-2 | 90.0 | 55.9 | [150] | ||
FZD1-2 | 85.5 | 94.2 | [151] | ||
BMP2-2 | 85.5 | 100.0 | [151] | ||
SPAM1-6 | 83.6 | 94.2 | [151] | ||
ITPR2-3 | 90.9 | 96.2 | [151] | ||
CPN2-1 | 90.9 | 98.1 | [151] | ||
TTC34-3 | 98.1 | 96.4 | [151] | ||
ACACA-1 | 94.2 | 100.0 | [151] | ||
LCP2-2 | 98.1 | 89.1 | [151] | ||
FOXG1-2 | 96.2 | 89.1 | [151] | ||
RP3-368B9.1.1-1 | 86.5 | 94.5 | [151] | ||
SLC30A4-1 | 90.9 | 96.2 | [151] | ||
Fer1L4 | 73.2 | 95.5 | [152] | ||
miRNA | Combination of miR-224-5p, miR-34b-3p and miR-182-5p | 80.3 | 66.3 | [153] | |
miRNA-135a-5p | 45.5 | 81.1 | [154] | ||
miR-720 | 80.0 | 100.0 | [155] | ||
miR-129-3p | 75.9 | 62.1 | [156] | ||
miR-182-5p | 90.0 | 97.0 | [81] | ||
Combination of miR-21 and miR-194 | 80.0 | 97.5 | [157] | ||
miR-142-3p | 62.0 | 56.0 | [158] | ||
miR-21 | 90.0 | 83.0 | [147] | ||
Combination of miR-10b, miR-139-5p, miR-130b and miR-199b | 76.0 | 100.0 | [159] | ||
Serum | LncRNA | LET | 70.8 | 59.3 | [138] |
LINC00887 | 71.1 | 89.9 | [160] | ||
PVT1 | 70.8 | 63.0 | [138] | ||
PANDAR | 75.0 | 63.0 | [138] | ||
PTENP1 | 79.2 | 77.8 | [138] | ||
Linc00963 | 83.3 | 66.7 | [138] | ||
GIHCG | 87.0 | 84.8 | [137] | ||
miRNA | Combination of miR-378 and miR-210 | 80.0–83.8 | 57.1–78.0 | ||
Combination of miR-10a-5p, miR-10b-5p and miR-223-3p | 86.7 | 75.0 | [162] | ||
Combination of miR-21-5p, miR-150-5p, miR-145-5p and miR-146a-5p | 90.8 | 93.8 | [163] | ||
Combination of miR-378 and miR-451 | 81.0 | 83.0 | [146] | ||
miR-1233 | 77.4–81.0 | 37.6–76.0 | |||
miR-210 | 67.5–82.5 | 62.2–80.0 | |||
miR-106a | 78.1 | 75.0 | [168] | ||
miR-206 | 83.8 | 57.1 | [161] | ||
miR-34a | 80.8 | 80.0 | [148] | ||
miR-141 | 75.0 | 73.3 | [148] | ||
Urine | miRNA | miR-15a | 98.1 | 100.0 | [169] |
miR-30a-5p me | 63.0 | 67.0 | [170] | ||
miR-210 | 57.8 | 80.0 | [171] | ||
miR-30c-5p | 68.6 | 100.0 | [172] | ||
Combination of miR-122, miR-1271 and miR-15b | 100.0 | 86.0 | [173] | ||
let-7 | 71.0 | 81.0 | [174] | ||
Combination of miR-122-5p, miR-1271-5p and miR-15b-5p | 96.0 | 65.0 | [175] | ||
Plasma | miRNA | miR-210 | 60.9 | 73.1 | [176] |
miR-221 | 71.4 | 65.0 | [176] | ||
miR-1233 | 39.1 | 92.6 | [176] | ||
miR-424-3p | 75.0 | 81.8 | [177] | ||
miR-144-3p | 87.1 | 83.0 | [178] | ||