Table 4 Univariate Cox regression analysis of overall survival (OS) in patients with colorectal cancer
Parameters | Univariable analysis HR (95% CI) | P-value | Parameters | Univariable analysis HR (95% CI) | P-value |
|---|---|---|---|---|---|
Sex | TLS | ||||
Male | 1 | 0.174 | Absent | 1 | 0.415 |
Female | 0.679 (0.388–1.187) | Present | 0.760 (0.394–1.469) | ||
Age | CD45RO.CT | ||||
< 63 | 1 | 0.799 | Low | 1 | 0.137 |
≥ 63 | 1.070 (0.635–1.802) | High | 1.511 (0.877–2.603) | ||
Tumor side | CD45RO.IM | ||||
Right | 1 | 0.119 | Low | 1 | 0.049* |
Left | 1.569 (0.891–2.762) | High | 0.653 (0.380–1.123) | ||
Tumor size | LAG3.CT | ||||
< 5 | 1 | 0.549 | Low | 1 | 0.226 |
≥ 5 | 1.178 (0.689–2.015) | High | 0.656 (0.331–1.299) | ||
Differentiation grade | LAG3.IM | ||||
Low grade | 1 | 0.205 | Low | 1 | 0.495 |
Moderate to high grade | 1.399 (0.832–2.353) | High | 1.206 (0.704–2.066) | ||
T stage | CD3.CT | ||||
T1/T2 | 1 | 0.060 | Low | 1 | 0.211 |
T3/T4 | 1.760 (0.976–3.176) | High | 1.394 (0.828–2.344) | ||
Lymph node involvement | CD3.IM | ||||
Absent | 1 | < 0.001*** | Low | 1 | 0.640 |
Present | 2.713 (1.611–4.568) | High | 1.133 (0.672–1.908) | ||
M stage | CD8.CT | ||||
M0 | 1 | < 0.001*** | Low | 1 | 0.533 |
M1 | 7.443 (3.741–14.808) | High | 1.180 (0.702–1.983) | ||
TNM stage | CD8.IM | ||||
I/II | 1 | < 0.001*** | Low | 1 | 0.482 |
III/IV | 3.529 (2.074–6.006) | High | 0.821 (0.473–1.424) | ||
Lymphovascular invasion (LVI) | CD45RO.IM/CT | ||||
Absent | 1 | 0.663 | Low to low | 1 | 0.047* |
Present | 1.123 (0.666–1.896) | CT high / IM low | 1.699(0.773–3.734) | 0.187 | |
Perineural invasion | CT low / IM high | 0.444(0.209–0.941) | 0.034* | ||
Absent | 1 | 0.140 | High to high | 0.956(0.486–1.880) | 0.896 |
Present | 1.576 (0.862–2.881) | LAG3.IM/CT | |||
Tumor budding | Low to low | 1 | 0.290 | ||
Low | 1 | 0.065 | CT high / IM low | 1.362(0.182–10.175) | 0.763 |
High | 1.643 (0.970–2.783) | CT low / IM high | 1.509(0.846–2.691) | 0.164 | |
High to high | 0.778(0.354–1.710) | 0.532 | |||