From: Molecular mechanisms of microRNA-216a during tumor progression
Study | Year | Type | Target | Samples | Function | Clinical Application |
---|---|---|---|---|---|---|
Zhao [17] | 2020 | Cervical cancer | ACTL6A | 45 T 45N tissues CaSki, C‐33A, HeLa, and SiHa cell lines | Tumor suppressor | Diagnosis |
Hou [28] | 2015 | Pancreatic cancer | JAK-2 | 14 T 6N tissues PANC-1, HPDE6c7, BxPC3, CFPAC-1, and Aspc-1 cell lines BALB/c nude mice | Tumor suppressor | Diagnosis |
Jin [29] | 2018 | Ovarian cancer | PTEN | SKOV3 and OVCA433 cell lines | Oncogene | Diagnosis |
Cao [34] | 2019 | Glioma | JAK2 | U251 cell line | Tumor suppressor | Diagnosis |
Tao [35] | 2017 | Gastric cancer | JAK2/STAT3 | 90 T 90N tissues SGC-7901, MGC-803, MKN-28, and BGC-823 cell lines BALB/c nude mice | Tumor suppressor | Diagnosis and prognosis |
Wan [41] | 2020 | Hepatocellular carcinoma | MAPK14 | 60 T tissues Huh-7, HepG2, and PLC/PRF/5 cell lines BALB/c nude mice | Tumor suppressor | Diagnosis and prognosis |
Zhang [44] | 2017 | Colorectal cancer | KIAA1199/CEMIP | 70 T 70N tissues HCT116, SW480, HT29, LOVO and SW620 cell lines NOD/SCID mice | Tumor suppressor | Diagnosis and prognosis |
Bai [49] | 2019 | Hepatocellular carcinoma | PTEN/ Smad7 | HCCLM3 cell line | Oncogene | Diagnosis |
Cui [50] | 2020 | Ovarian cancer | PTEN | 60 T 60N tissues UWB1.289 cell line | Oncogene | Diagnosis |
Liu [51] | 2017 | Ovarian cancer | PTEN/AKT | 87 T 25N tissues SKOV-3, HO-8910, A2780, ES-2, CAOV3, and OVCAR3 cell lines | Oncogene | Diagnosis and prognosis |
Wang [53] | 2021 | Pancreatic cancer | WT1 | 71 T 71N tissues AsPC-1, BxPC-3, PANC-1, MIA PaCa-2, and SW1990 cell lines BALB/c nude mice | Tumor suppressor | Diagnosis and prognosis |
Yang [60] | 2018 | Prostate cancer | BCL-2 | 86 T 86N tissues DU145, PC3, LNCaP, and 22Rv1 cell lines | Tumor suppressor | Diagnosis and prognosis |
Yu [66] | 2020 | Non-small cell lung cancer | Wnt | A549, H1975, H1755, H1944, H2087, H358, H661 and H1299 cell lines | Tumor suppressor | Diagnosis |
Zhang [71] | 2017 | glioma | LGR5 | 15 T 15N tissues U251MG, U87MG, U118, and A172 cell lines | Tumor suppressor | Diagnosis |
Lu [92] | 2017 | Pancreatic cancer | YB-1 | 72 T 72N tissues Panc-1 and Miapaca-2 cell lines | Tumor suppressor | Diagnosis |
Li [95] | 2021 | Large B-Cell Lymphoma | YBX1 | DB, SU-DHL-10, and SU-DHL-4 cell lines | Tumor suppressor | Diagnosis |
Zeng [96] | 2019 | Colorectal cancer | YBX1 | 70 T 70N tissues LoVo, SW480, HT-29, HCT-116, and Caco-2 cell lines | Tumor suppressor | Diagnosis and prognosis |
Song [98] | 2019 | Gastric cancer | BRD4 | 36 T 36N tissues AGS, BGC-823, MKN-45, MGC-803, and SCG-7901 cell lines | Tumor suppressor | Diagnosis |
Sun [103] | 2021 | Esophageal cancer | HMBG3 | 68 T 68N tissues TE-1, TE-9, KYSE30, EC9706 cell lines | Tumor suppressor | Diagnosis |
Wang [104] | 2019 | Hepatocellular carcinoma | KLF12 | Hep3B, HepG2, Huh7, SNU449, SK‐hep‐1, and LO2 cell lines BALB/c nude mice | Tumor suppressor | Diagnosis |
Qu [105] | 2020 | Oral squamous cell carcinoma | BCL-2/ KLF-12 | 86 T 86N tissues SCC9, SCC15, SCC25, CAL27 and Tca8113 cell lines BALB/c nude mice | Tumor suppressor | Diagnosis and prognosis |
Pan [109] | 2020 | Osteosarcoma | SOX5 | 45 T 45N tissues MG-63, U2OS, 143B cell lines BALB/C nude mice | Tumor suppressor | Diagnosis and prognosis |
Zhen [110] | 2018 | Lung cancer | DANCR | 32 T 11N tissues BEAS-2B, NCI-H1299, A549, and NCI-H1975 cell lines Nude mice | Tumor suppressor | Diagnosis and prognosis |
Zhu [114] | 2018 | Cervical cancer | ZEB1 | 60 T 18N tissues HeLa, CaSki, SiHa, and C33A cell lines | Tumor suppressor | Diagnosis and prognosis |
Zhao [115] | 2020 | Non-Small Cell Lung Cancer | ZEB1 | 42 T 42N tissues A549, H322, H1299, GLC-82, and SPC-A1 cell lines BALB/c nude mice | Tumor suppressor | Diagnosis and prognosis |
Zhang [118] | 2018 | Gastric cancer | RUNX1 | 140 T 140N tissues AGS, MKN-45, and HGC-27 cell lines | Oncogene | Diagnosis and prognosis |
Zhang [124] | 2015 | Pancreatic cancer | beclin-1 | PANC-1 cell line BALB/c nude mice | Tumor suppressor | Diagnosis |
Zhao [125] | 2020 | Gastric cancer | BCL-2 | 106 T 106N tissues SGC7901 cell line BALB/c nude mice | Tumor suppressor | Diagnosis and prognosis |
Wang [128] | 2019 | Colorectal cancer | MAP1S | 67 T 67N tissues HT-29, HCT-116, SW-480, and SW-62 cell lines | Tumor suppressor | Diagnosis |
Zhang [132] | 2020 | Pancreatic cancer | TPT1/mTORC1 | 40 T 40N tissues SW1990, PANC1, Capan-2 and BxPC-3 cell lines SCID mice | Tumor suppressor | Diagnosis and prognosis |
Zhou [135] | 2021 | Oral squamous cell carcinoma | BCL2L2 | 30 T 30N tissues CAL27 and SCC25 cell lines BALB/c nude mice | Tumor suppressor | Diagnosis |
Sun [137] | 2018 | Small cell lung cancer | BCL-2 | NCI-H69, NCI-H69AR, NCI-H446, and 16-HBE cell lines BALB/c nude mice | Tumor suppressor | Diagnosis |
Ji [144] | 2017 | osteosarcoma | CDK14 | 91 T 91N tissues U2OS and 143B cell lines BALB/c nude mice | Tumor suppressor | Diagnosis and prognosis |
Lin [148] | 2021 | Bladder carcinoma | BTG2 | 21 T 21N tissues EJ, T24, 5637, TCC-SUP cell lines | Oncogene | Diagnosis |
Roscigno [159] | 2020 | Breast cancer | TLR4 | T47D and MDA-MB-MB-231cell lines | Tumor suppressor | Diagnosis |
Wang [160] | 2018 | Renal cell carcinoma | TRL4 | 27 T 27N tissues 786-O, ACHN, Caki-1, A498, GRC-1 and OS-RC-2 cell lines BALB/c nude mice | Tumor suppressor | Diagnosis |
Wang [162] | 2018 | Colorectal cancer | COX-2/ALOX5 | 42 T 42N tissues HT29, HCT15, SW480 and SW1116 cell lines | Tumor suppressor | Diagnosis and prognosis |
Liu [168] | 2018 | Melanoma | HK2 | 86 T tissues HEK293T cell line BALB/c nude mice | Tumor suppressor | Diagnosis and prognosis |
Pang [171] | 2021 | Non-small cell lung cancer | RAP2B | 35 T 35N tissues A549 and NCI-H1299 cell lines BALB/C nude mice | Tumor suppressor | Diagnosis and prognosis |
Li [174] | 2022 | Cervical cancer | CDC42 | 31 T 31N tissues SiHa, HeLa, and 293 T cell lines BALB/c nude mice | Tumor suppressor | Diagnosis and prognosis |
Zhang [180] | 2019 | Breast cancer | PAK2 | 50 T 50N tissues BC MCF-7 cell line | Tumor suppressor | Diagnosis |
Cui [185] | 2019 | Breast cancer | PKCα | 10 T 10N tissues MCF-7, MD-MB231, MDA-MB-468, and SK-BR3 cell lines | Tumor suppressor | Diagnosis |
Wang [191] | 2020 | Lung adenocarcinoma | COPB2 | H1299, A549, SK-MES-1, NCI-H23, and H1975 cell lines | Tumor suppressor | Diagnosis |
Peng [194] | 2020 | Glioma | AQP4 | 50 T 50N tissues U251, A172, T98G, HS683, and U138 cell lines BALB/c nude mice | Tumor suppressor | Diagnosis |
Wang [201] | 2020 | Pancreatic cancer | TSPAN1 | PANC-1, BxPC3, and ASPC1 cell lines | Tumor suppressor | Diagnosis |
Sun [206] | 2020 | Esophageal cancer | KIAA0101 | 83 T 83N tissues EC9706, EC109, KYSE150, KYSE450, TE1, and TE10 cell lines | Tumor suppressor | Diagnosis and prognosis |