MicroRNA-122 in human cancers: from mechanistic to clinical perspectives

Faramin Lashkarian, Mahboobeh; Hashemipour, Nasrin; Niaraki, Negin; Soghala, Shahrad; Moradi, Ali; Sarhangi, Sareh; Hatami, Mahsa; Aghaei-Zarch, Fatemehsadat; Khosravifar, Mina; Mohammadzadeh, Alireza; Najafi, Sajad; Majidpoor, Jamal; Farnia, Poopak; Aghaei-Zarch, Seyed Mohsen

doi:10.1186/s12935-023-02868-z

Cancer Cell International

Table 1 miR-122 expression in human cancer

From: MicroRNA-122 in human cancers: from mechanistic to clinical perspectives

Cancer	Author/year	Verified target	Remark	Expression levels	Sample	miR-122/lncRNA or circular RNA axis	Tumor suppressor/Enhancer	Refs.
Liver	Barajas et al./2018	G6PD	Modulate glucose metabolism in liver cancer	↓	Cell lines	–	Suppressor	[18]
	Li et al./2020	LMNB2	Inhibit hepatocarcinoma progression	↓	Tissues samples/cell lines	–	Suppressor	[19]
	Li et al./2019	APOBEC2	Involved in HBV infection	↓	Cell lines	–	Suppressor	[21]
	Cheng et al./2018	–	Blocked tumorigenicity	↓	Tissues samples/cell lines	lncRNA-HOTAIR	Suppressor	[22]
	Lee et al./2021	–	Increased serum levels of miR-122-5p associated with increased risk of incident LC in T2D	↑	Serum samples	–	Enhancer	[23]
	Zhan et al./2021	–	Can predict LC patient responses to sorafenib chemotherapy	↓	Tissues samples	–	Suppressor	[76]
	Yin et al./2016	TGFβ1	Exerts markedly different effects on metastatic liver cancer in humans and mice	↓	Cell lines	–	Suppressor	[111]
	Shyu et al./2016	PEG10	Serve as early biomarkers for identifying an HCC subpopulation that is at high risk for poor outcome	↓	Tissues samples/cell lines	–	Suppressor	[112]
	Akuta et al./2022	–	Predicting LC for NAFLD patients with severe fibrosis stage	↓	Serum samples	–		[77]
	Coulouarn et al./2009		An important determinant in the control of cell migration and invasion	↓	Tissues samples/cell lines	–	Suppressor	[113]
Gastric	Meng et al./2020	LYN	Inhibited the proliferation, migration, and invasion	↓	Tissues samples/cell lines	–	Suppressor	[24]
	Xu et al./2018	DUSP4	Restrained migration and invasion	↓	Tissues samples/cell lines	–	Suppressor	[25]
	Rao et al./2017	CREB1	Inhibited GC tumorigenesis	↓	Tissues samples/cell lines	–	Suppressor	[26]
	Pei et al./2017	MYC	Inhibits tumor cell proliferation and induces apoptosis	↓	Cell lines	–	Suppressor	[27]
	Chen et al./2014	–	Function as potential novel biomarkers for the early detection of distant metastasis	↓	Cell lines/plasma samples	–	Suppressor	[78]
	Maruyama et al./2019	FOXO3	Inhibited apoptosis	↑	Tissues samples/cell lines	–	Enhancer	[28]
	Maruyama et al./2018	–	Useful biomarker for early detection and disease monitoring	↑	Tissues samples	–	Enhancer	[79]
	Qin et al./2018	MMP-9	Suppressed proliferation, migration and invasion, and promoted apoptosis	↓	Tissues samples/cell lines	lncRNA-01296	Suppressor	[114]
Bile duct	Xu et al./2018	ALDOA	Inhibited proliferation and invasion	↓	Cell culture/tissue samples	–	Suppressor	[29]
	Kong et al./2019	CLIC1	Inhibited Bile duct carcinoma progression	↓	Cell line	LncRNA-UCA1	Suppressor	[30]
	Zhu et al./2016	–	Inhibited cell proliferation	↓	Cell culture/tissue samples	–	Suppressor	[31]
	Loosen et al./2019	–	Promising tool for the diagnosis of even early stage CCA	↑	Serum samples	–	Enhancer	[73]
Colorectal	Wang et al./2020	PKM2	Reversion of oxaliplatin resistance in CRC	↓	Cell culture/tissue samples	hsa_circ_0005963	Suppressor	[83]
	Yin et al./2020	CDC25A	Inhibited CRC progression	↓	Cell culture/tissue samples	circ_0007142	Suppressor	[32]
	Sun et al./2020	–	As a potential diagnostic and prognostic biomarker	↑	Serum samples/Cell culture	–	Enhancer	[33]
	Maierthaler et al./2017	–	As a potential prognostic biomarker	↑	Plasma samples	–	Enhancer	[80]
Colon	Li et al./2019	ALDOA	Promotes the proliferation and invasion	↑	Cell line	–	Enhancer	[34]
Esophageal	Wang et al./2021	KIF22	Blocked cell proliferation, migration and invasion	↓	Cell culture/tissue samples	–	Suppressor	[35]
Esophageal	Zhang et al./2016	PKM2	Functioned on growth inhibition	↓	Cell line	–	Suppressor	[36]
Gallbladder	Lu et al./2016	PKM2	Inhibits cancer cell malignancy	↓	Cell line/Tissue samples	–	Suppressor	[37]
Nasopharyngeal	Liu et al./2019	SATB1	Suppresses cell proliferation, migration and invasion	↓	Cell Line	–	Suppressor	[38]
Breast	Fong et al./2015	PKM	Reprograms glucose metabolism in premetastatic niche to promote metastasis	↑	Cell culture/tissue samples	–	Enhancer	[39]
	Wang et al./2020	CHMP3	promotes aggression and EMT in TNBC	↑	cell line	–	Enhancer	[40]
	Wang et al./2012	IGF1R	Plays an important role in inhibiting the tumorigenesis	↓	Cell culture/tissue samples	–	Suppressor	[41]
	Zhang et al./2019	Bcl-2/CDKs	Enhance the chemosensitivity of breast cancer	↑	Cell line	–	Enhancer	[88]
	Perez‐Añorve et al./2019	ZNF611/ZNF304	Controls the response to radiotherapy	↑	Cell line	–	Enhancer	[86]
	Qin et al./2021	STK39	Inhibited breast cancer progression	↓	Cell culture/tissue samples	LncRNA-CDKN2B-AS1	Suppressor	[42]
	Uen et al./2018	syndecan-1	Increased breast cancer cell mobility	↑	Cell line	–	Enhancer	[115]
	Zhang et al./2018		Inhibited breast cancer progression	↓	Cell line	LncRNA-RPPH1	Suppressor	[116]
	Ergün et al./2015	ADAM10	Potential regulator of trastuzumab resistance	↓	Tissue samples	–	Suppressor	[117]
	Saleh et al./2019	–	ASSOCIATED with decreased overall survival and progression-free survival	↑	Whole blood samples	–	Enhancer	[118]
Ovarian	Duan et al./2018	P4HA1	Inhibited migration, invasion, and EMT	↓	Cell culture/tissue samples	–	Suppressor	[43]
Ovarian	Huang et al./2022	SLC1A5	Suppressed cell proliferation, migration, invasion and accelerated cell apoptosis	↓	Cell culture/tissue samples	Circ_0072995	Suppressor	[44]
Bladder	Wang et al./2016	VEGFC	Regulated cell proliferation	↓	Cell culture/tissue samples	–	Suppressor	[45]
Bladder	Guo et al./2018	CREB1	Regulated cell proliferation and invasion	↓	Cell culture/tissue samples	–	Suppressor	[46]
Cervical	Ding et al./2019	CDC25A	Modulates the radiosensitivity of cervical cancer cells	↓	Cell culture/tissue samples	–	Suppressor	[87]
Cervical	Yang et al./2022	RAD21	Block malignant growth and promoted apoptosis	↓	Cell culture/tissue samples	–	Suppressor	[47]
Pancreatic	Hu et al./2021	–	Suppressed cell proliferation and invasion	↓	Cell line/tissue samples	LncRNA PART1 p	Suppressor	[48]
	Yin et al./2020	XIAP	Restraining tumorigenic ability	↓	Cell line	LncRNA SBF2-AS1	Suppressor	[49]
	Dai et al./2020	CCNG1	Inhibit cell proliferation, migration, invasion, and EMT	↓	Cell line/tissue samples	–	Suppressor	[50]
	Mazza et al./2020	–	Associated with worse prognosis and clinical outcome	↑	Plasma samples	–	Enhancer	[74]
	Cui et al./2018	ALDOA	Blocked proliferation and invasion	↓	Cell line	lncRNA DIO3OS	Suppressor	[119]
Prostate	Liu et al./2019	ROCK2	Inhibit cell proliferation	↓	Cell line/serum samples	–	Suppressor	[51]
Prostate	Zhu et al./2020	PKM2	Reverse the resistance of LNCaP/Docetaxel cells to docetaxel	↓	Cell line	–	Suppressor	[90]
Thyroid	Hu et al./2021	DUSP4	inhibited the proliferation, invasion, and migration	↓	Cell line/tissue samples	–	Suppressor	[52]
Renal	Wang et al./2019	PKM2	Promotes cancer cell viability, proliferation, migration, glycolysis and autophagy	↑	Cell line	–	Enhancer	[53]
	Lian et al./2013	–	Promotes proliferation, invasion and migration	↑	Cell line	–	Enhancer	[54]
	Wang et al./2017	Sprouty2	Act as a tumor promoter	↑	Cell line/tissue samples	–	Enhancer	[55]
	Fan et al./2018	Dicer	Promotes metastatic behavior	↑	Cell line/tissue samples	–	Enhancer	[56]
	Heinemann et al./2018	–	High serum miR-122-levels indicate advanced stage/grade	↑	Serum samples	–	Enhancer	[57]
	Cochetti et al./2022		Aid in the early diagnosis	↑	Urinary samples		Enhancer	[120]
Lung	Li et al./2021	–	Mediated lung cancer progression	↑	Cell line	–	Enhancer	[58]
	Gao et al./2020	FSTL3	Reversed the proliferation and metastasis	↓	Cell line/tissue samples	lncRNA DSCAM-AS1	Suppressor	[59]
	Ma et al./2015	–	Induces radiosensitization	↓	Cell line	–	Suppressor	[60]
	Chandimali et al./2019	Prx II	inhibited cancer stem cell proliferation\	↓	Cell line	–	Suppressor	[61]
	Zhao et al./2015	CCNG1/MEF2D	Induced cell cycle arrest	↓	Cell line/tissue samples	–	Suppressor	[121]
Osteosarcoma	Ma et al./2021	–	Inhibited the proliferation, invasion, and migration	↓	Cell line/tissue samples	LINC01410	Suppressor	[62]
	Li et al./2020	TP53	Inhibit the proliferation and promote the apoptosis of osteosarcoma cells	↓	Cell line/tissue samples	–	Suppressor	[63]
	Yuan et al./2020	ADAM10	Induced inhibition of cell proliferation, migration, and invasion	↓	Cell line	–	Suppressor	[64]
Glioma	Sun et al./2018	–	Repressed the Proliferation, Migration, and Invasion	↓	Cell line/tissue samples	lncRNA UCA1	Suppressor	[67]
	Wang et al./2014	WNT1	Repressed the Proliferation	↓	Cell line/tissue samples	–	Suppressor	[68]
	Tang et al./2017	–	Function as a diagnostic and prognostic biomarker	↓	Plasma samples	–	Suppressor	[75]
Hematological	Yang et al./2017	–	Serve as a prognostic factor in AML	↓	Cell culture/tissue samples	–	Suppressor	[69]
Hematological	Beg et al./2021	–	Involved in imatinib response in CML patients	↓	tissue samples	–	Suppressor	[70]
Melanoma	Li et al./2018	NOP14	Inhibits the proliferation	↑	Cell culture/tissue samples	–	Enhancer	[71]
Oral squamous cell carcinoma	Tian et al./2021	RhoA	Blocked cell invasion and migration	↓	Cell line/tissue samples	LINC00974	Suppressor	[72]

Back to article page

ISSN: 1475-2867

Contact us

General enquiries: journalsubmissions@springernature.com