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Fig. 1 | Cancer Cell International

Fig. 1

From: Chorioallantoic membrane assay revealed the role of TIPARP (2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible poly (ADP-ribose) polymerase) in lung adenocarcinoma-induced angiogenesis

Fig. 1

The chorioallantoic membrane (CAM) assay as a model for researching lung cancer engraftment and angiogenesis. a. A schematic diagram of the CAM assay. b. Macroscopic images are captured on embryonic development day (EDD) 10, 11, 13 and 15. A cell line-derived organoid engrafts the CAM and induces angiogenesis (upper panels). The red arrowheads indicate transplanted organoids. The right image shows an enlarged bottom view of the area enveloped by the yellow dotted lines. The sphere formation medium does not recruit the vessels (lower panels). c. Microscopic images show graft-induced angiogenesis in the CAM assay on EDD 15. A cell line-derived organoid recruited microvessels from thick vessels (right panels). Upper and lower panels were captured at 0.67 × and 1.5 × magnification. Yellow arrowheads indicate new vessels on the mass surface

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Cancer Cell International

ISSN: 1475-2867

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