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Fig. 7 | Cancer Cell International

Fig. 7

From: Krüppel-like factor 9 (KLF9) links hormone dysregulation and circadian disruption to breast cancer pathogenesis

Fig. 7

Circadian-hormone-KLF9 crosstalk in BCa. The KLF9 gene is coordinately regulated by GC (#1) and circadian (#2) signaling in normal breast epithelial cells. KLF9, in turn, feed backs to the breast circadian oscillator by modulating the GC (#3) and E2 (#4) response of core clock genes. In the context of BCa progression, KLF9 restricts oncogenesis in all mammary epithelial cell models used (#5). Moreover, in the luminal ER-expressing MCF7 cells, KLF9 enhanced the anti-tumorigenic effects of CORT signaling, while in triple-negative MCF10A and MDA-MB-231 cells, KLF9 restricted CORT-induced BCa progression

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Cancer Cell International

ISSN: 1475-2867

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