Name of TF model | Position | Sequence | Strand | Score | P-value | E-value |
|---|
GRα (T00337) | eKSM (−4602 bp) | ggagcttgatgttcc | − | 152.1 | 2.5 × 10–5 | 0.0165 |
aKSM (−5467 bp) | ggaacagtttgtcct | + | 137.82 | 0.0004 | 0.157 |
KDE GRE1 (−66,198 bp) | atcaacagcatgatct | − | 146.27 | 0.000125 | 0.064 |
KDE GRE2 (−66,248 bp) | cagtacagaatgttct | + | 224.4 | 0 | 0 |
ER (M00191) | eKSM ERE (−4696 bp) | ccacgcccacgtgagctaa | + | 8.19 | 0.00095 | 0.63 |
- Positions are indicated are either in the ± strand and are relative to the TSS which is set as the zero position. Scores are obtained for the GR-alpha transcription factor model from the TRANSFAC database (T00337) or ER (M00191) based on position-specific scoring matrices. The P-value is empirically determined from the position-specific scoring matrices scores of individual nucleotides in the sequence relative to the TF model and is indicative of the probability of observing a score equal to or higher than the score by chance. The E-value considers the length of the genomic region being tested and gives the number of expected times a hit of the same or higher score is found in the genomic region by chance [51]
