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Fig. 8 | Cancer Cell International

Fig. 8

From: Anterior gradient 2 induces resistance to sorafenib via endoplasmic reticulum stress regulation in hepatocellular carcinoma

Fig. 8

Proposed model of the roles of AGR2 in sorafenib-sensitive and sorafenib-resistant HCC. AGR2 plays different roles in sorafenib-sensitive (PC) and sorafenib-resistant (SR) cells. Sorafenib decreases AGR2 expression in the cell lysate and in turn induces secretion into CM. Sorafenib reduces cell viability and induces cell apoptosis. However, AGR2 is highly expressed in sorafenib-resistant cells, and the induction of AGR2 expression in CM was more robust in sorafenib-resistant cells than in parental cells, which in turn induces cell survival and suppresses cell apoptosis

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Cancer Cell International

ISSN: 1475-2867

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