Cancer Cell International

Table 6 Prognostic significance of clinicopathologic indicators and AGR2 for overall survival in the clinical cohort

From: Anterior gradient 2 induces resistance to sorafenib via endoplasmic reticulum stress regulation in hepatocellular carcinoma

Factor	OS univariate				OS multivariate
Factor	Group	HR	95% CI	P	HR	95% CI	P
Age	< 60/ ≥ 60 years	0.975	(0.638–1.490)	0.907
Sex	Male/female	1.407	(0.906–2.186)	0.936
Viral infection				0.281
	No/B	1.546	(0.890–2.685)	0.122
	No / C	1.014	(0.573–1.794)	0.962
	No / B + C	1.433	(0.704–2.916)	0.322
Cirrhosis	−/ +	1.632	(1.080–2.466)	0.020*	1.655	(1.093–2.505)	0.017*
Serum AFP	< 200/ ≥ 200 ng/ml	1.692	(1.122–2.551)	0.012*			NS
Differentiation	W/M-P	1.330	(0.851–2.079)	0.210
Tumor size	< 5/ ≥ 5 cm	1.101	(0.720–1.683)	0.658
Vascular invasion	−/ +	2.302	(1.458–3.635)	< 0.001*	2.200	(1.392–3.476)	0.001*
AJCC stage	I/ ≥ II	2.076	(1.224–3.521)	0.007*			NS
AGR2	Low/high	1.894	(1.114–3.221)	0.018*	1.945	(1.138–3.324)	0.015*

^*P < 0.05. OS, overall survival; Tumor differentiation according to WHO system; AFP, alpha-fetoprotein; AJCC, American Joint Committee on Cancer 2017

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