Skip to main content
Fig. 8 | Cancer Cell International

Fig. 8

From: Changes in calpain-2 expression during glioblastoma progression predisposes tumor cells to temozolomide resistance by minimizing DNA damage and p53-dependent apoptosis

Fig. 8

TP53BP1 expression and calpain-2 mediated DNA damage resistance mechanism. a TP53BP1 mRNA expression levels in U251N shCTRL and shCAPN2 cells. b Fluorescent staining for ɣH2AX (AF555, green) and TP53BP1 (AF647, red) in U251N shCTRL and shCAPN2 cells after NCS administration. Cell nuclei are stained with Hoechst (blue). c Schematic of the calpain-2 driven DNA damage resistance mechanism. Decreased calpain-2 expression leads to a perturbed DNA double strand break repair, followed by increased DNA damage and an enhanced DNA damage recognition by e.g. TP53, and enhanced apoptosis induction

Back to article page

Cancer Cell International

ISSN: 1475-2867

Contact us