Fig. 2

A The CNV mutation frequency of 59 polyamine metabolism (PAM) related genes was prevalent. The column represented the alteration frequency. The deletion frequency, green dot; The amplification frequency, red dot. B Kaplan–Meier curves of overall survival (OS) for 1224 CRC patients in meta cohort with different PAM clusters. The numbers of patients in PAMcluster-A, PAMcluster-B, and PAMcluster-C phenotypes are 547, 370 and 307, respectively (Log-rank test). C PCA analysis showing a remarkable difference in transcriptomes among the three clusters. D–G The proportion of mutation features in the three patterns based on GES39582