Skip to main content
Fig. 6 | Cancer Cell International

Fig. 6

From: PCK1 activates oncogenic autophagy via down-regulation Serine phosphorylation of UBAP2L and antagonizes colorectal cancer growth

Fig. 6

PCK1 over-expression inhibits CRC cell proliferation via decreasing Ser phosphorylation at UBAP2L 454. A and B CCK8 assays of PCK1-OE CRC cells with or without p-UBAP2L Ser 445, Ser 454, Ser 467, and Ser 477 mutations. C Calculated tumor volumes and weights in the p-UBAP2L Ser 454 ctrl and p-UBAP2L Ser 454 (A) groups 24 days after tumor cells were injected into the BALB/c- nude mice. (D) UBAP2L Ser 454 phosphorylation levels were analyzed by western blot analysis in PCK1-OE and PCK1-sh CRC cells. Actin was used as a control. *P < 0.05, **P < 0.01, and ***P < 0.001

Back to article page

Cancer Cell International

ISSN: 1475-2867

Contact us