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Fig. 4 | Cancer Cell International

Fig. 4

From: The role of the desmosomal protein desmocollin 2 in tumour progression in triple negative breast cancer patients

Fig. 4

Impact of DSC2 knock down and DSC2 overexpression on tumour cell proliferation, migration and chemosensitivity in 2D. A DSC2 overexpression in MDA-MB231 cells does not affect cell proliferation (upper panel). A slight increase in the proliferation rate was detected in one of the DSC2 knock out clones and only after 72 h cultivation (lower panel). B DSC2 overexpression in MDA-MB231 and DSC2 silencing in MDA-MB231-BR cells slightly but significantly decreased (upper panel) and increased (lower panel) the tumour cell migratory ability in a wound closure assay, respectively. C Both DSC2 overexpression (upper panel) and silencing (lower panel) did not show any impact on tumour cell chemosensitivity against cisplatin

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Cancer Cell International

ISSN: 1475-2867

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