Fig. 5

Hierarchical cluster analysis of gene expression data on TCGA UM Firehose Legacy Dataset. A Heatmap depicting the relative expression of the genes investigated on a cohort of 80 UM samples grouped by hierarchical cluster analysis. Each column represents one UM sample, and each row represents the indicated gene. The expression level of each gene in a single sample is depicted according to the color scale. B Fold change of the relative expression of FGF, FGFR and stemness genes in Cluster 1 (n = 29), Cluster 2 (n = 24), and Cluster 3 (n = 27). In box and whisker graphs, boxes extend from the 25th to the 75th percentiles, lines indicate the median values, and whiskers indicate the range of values. *p < 0.05, **p < 0.01, ANOVA. C Kaplan–Meier curve displaying Disease-Free Survival (DFS) of patients belonging to Cluster 1, Cluster 2, or Cluster 3. Log-rank test p-value. Relative units, RU