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Fig. 7 | Cancer Cell International

Fig. 7

From: The relationship between sphingosine-1-phosphate receptor 2 and epidermal growth factor in migration and invasion of oral squamous cell carcinoma

Fig. 7

Proposed crosstalk between EGF and S1PR2 in H357, H400 and H413 cells. Sphk1 transcription is elevated following EGF treatment, resulting in the production of S1P. After being exported into the intercellular space, it binds to S1PR2, further generating a signal required for migration and invasion. EGF and S1PR2 co-ordinately regulates motility and Rac1 activity of H357, H400 and H413 cells. Rac1 controls cytoskeleton organisation via IRSp53/WAVE proteins/Apr2/3 pathway and PAK1/LIMK1 pathway, but this role (red arrow) has not yet been substantiated in the present study. (Diagram created using BioRender.com).

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Cancer Cell International

ISSN: 1475-2867

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