A novel NHEJ gene signature based model for risk stratification and prognosis prediction in hepatocellular carcinoma

Table 2 KEGG enrichment analysis between the high- and low-risk subgroups in TCGA training cohort and the GEO validation cohort

KEGG ID	ES	p-value	FDR
TCGA cohort
DNA replication	− 0.8061	0.002	0.0407
Mismatch repair	− 0.7773	0.0019	0.0458
Homologous recombination	− 0.775	0	0.0411
Cell cycle	− 0.7281	0	0.0354
Non homologous end joining	− 0.6846	0.0313	0.0963
Primary bile acid biosynthesis	0.9432	0	0.006
Fatty acid metabolism	0.852	0	0.0064
Glycine serine and threonine metabolism	0.7974	0	0.0107
Retinol metabolism	0.7732	0	0.0044
valine leucine and isoleucine degradation	0.7507	0.0061	0.011
GEO cohort
DNA replication	− 0.8487	0	0.0383
Homologous recombination	− 0.769	0	0.0293
Mismatch repair	− 0.7485	0.002	0.0435
Non homologous end joining	− 0.6924	0.002	0.0948
Cell cycle	− 0.69	0	0.0256
Primary bile acid biosynthesis	0.9223	0	0.0109
Retinol metabolism	0.8294	0.002	0.0132
Fatty acid metabolism	0.8283	0	0.0093
Glycine serine and threonine metabolism	0.8251	0.0021	0.0139

ES, Enrichment Score. Positive ES indicates enrichment in low-risk group; Negative ES indicates enrichment in high-risk group

ISSN: 1475-2867