Table 4 Impact of ATG4B expression levels on disease-free survival by the different demographic and clinicopathologic factors with colorectal cancer
From: ATG4B and pS383/392-ATG4B serve as potential biomarkers and therapeutic targets of colorectal cancer
Variable | No. (%) | CHR (95% CI) | p value* | AHR (95% CI) | p value †| |
|---|---|---|---|---|---|---|
Sex | ||||||
 Female | Low | 25 (53.5) | 1.00 | 1.00 | ||
High | 22 (46.5) | 1.70 (0.76–3.84) | 0.199 | 3.18 (1.30–7.80) | 0.012 a | |
 Male | Low | 38 (53.2) | 1.00 | 1.00 | ||
High | 33 (46.8) | 2.79 (1.41–5.54) | 0.003 | 6.78 (2.89–15.88) | < 0.001 a | |
Age, yrs | ||||||
 ≦ 60 | Low | 22 (48.9) | 1.00 | 1.00 | ||
High | 23 (51.1) | 2.01 (0.87–4.61) | 0.102 | 3.55 (1.41–8.94) | 0.007 a | |
 >60 | Low | 41 (56.2) | 1.00 | 1.00 | ||
High | 32 (43.8) | 2.51 (1.28–4.92) | 0.007 | 5.62 (2.50-12.66) | < 0.001 a | |
Cell differentiation | ||||||
 Well | Low | 3 (68.0) | 1.00 | 1.00 | ||
High | 1 (32.0) | 434.45 (0.00-8.954E + 12) | 0.616 | 434.45 (0.00-8.954E + 12) | 0.616b | |
 Moderate, poor | Low | 60 (44.1) | 1.00 | 1.00 | ||
High | 54 (55.9) | 2.24 (1.31–3.81) | 0.003 | 5.17 (2.80–9.54) | < 0.001 b | |
AJCC pathological stage | ||||||
 I, II | Low | 12 (57.1) | 1.00 | 1.00 | ||
High | 9 (42.9) | 3.11 (1.03–9.38) | 0.044 | 3.60 (1.04–12.46) | 0.043 c | |
 III, IV | Low | 51 (52.6) | 1.00 | 1.00 | ||
High | 46 (47.4) | 4.41 (2.24–8.68) | < 0.001 | 4.37 (2.21–8.65) | < 0.001 c | |
T classification | ||||||
 T1, T2 | Low | 12 (57.1) | 1.00 | 1.00 | ||
High | 9 (42.9) | 3.22 (0.59–17.64) | 0.178 | 5.50 (0.61–49.32) | 0.128d | |
 T3, T4 | Low | 51 (52.6) | 1.00 | 1.00 | ||
High | 46 (47.4) | 2.18 (1.26–3.78) | 0.005 | 3.73 (2.00-6.98) | < 0.001 d | |
N classification | ||||||
 N0 | Low | 27 (42.2) | 1.00 | 1.00 | ||
High | 37 (57.8) | 2.33 (0.98–5.56) | 0.056 | 2.18 (0.86–5.53) | 0.102e | |
 N1, N2 | Low | 36 (66.7) | 1.00 | 1.00 | ||
High | 18 (33.3) | 4.75 (2.29–9.86) | < 0.001 | 4.69 (2.24–9.80) | < 0.001 e | |
Postoperative RT | ||||||
 No | Low | 56 (50.9) | 1.00 | 1.00 | ||
High | 54 (49.1) | 2.32 (1.34–4.02) | 0.003 | 4.67 (2.53–8.64) | < 0.001 a | |
 Yes | Low | 7 (87.5) | 1.00 | 1.00 | ||
High | 1 (12.5) | 2.96 (0.27–32.84) | 0.376 | 2.96 (0.27–32.84) | 0.376a |