Fig. 6

Dose-dependent effects of ACT-903 on tumor volume. A Tumor volume. Each dose group (n = 10 per group) was administered either 10, 20, 30, 40 or 50 mg/kg of ACT-903 or 25 mg/kg of ACT-101 (targeting protein only) or vehicle control by IV tail injection. Dose 1 was administered to all animals on Day 9. A second dose (Dose 2) was administered to animals in the 40 and 50 mg/kg groups (G1 and G2) on Day 24 post tumor implantation. Statistical significance was determined by Kruskal Wallace & Dunnett’s on Ranks, followed by Wilcoxon test. B Tumor volume linear regression. Effect of first dose on tumor growth kinetics using linear regression analysis of the tumor volumes over time between the first and second doses