Skip to main content
Fig. 8 | Cancer Cell International

Fig. 8

From: High anti-tumor activity of a novel alpha-fetoprotein-maytansinoid conjugate targeting alpha-fetoprotein receptors in colorectal cancer xenograft model

Fig. 8

Dual tumor targeting mechanism of ACT-101 conjugates. Once ACT-101 conjugate (blue Y shape with toxins attached (small yellow star shapes) binds to the AFP receptor (grey Y shape), the conjugate is endocytosed and transported to the interior of the cell, where high glutathione (GSH) concentrations result in linker cleavage and release of the cytotoxic payload. Some of the ACT-101 may be transported outside the cell by recycling endosomes

Back to article page

Cancer Cell International

ISSN: 1475-2867

Contact us