Fig. 2

MRCCGs patterns and clinicopathological characteristics

(A) Interactions among MRCCGs in STAD. The line connecting the MRCCGs represents their interactions, with the line thickness indicating the strength of the association between MRCCGs. The size of each circle indicates the different significance of each gene. Blue and pink represent negative and positive correlations, respectively. Favorable factors are indicated in green, and risk factors are indicated in purple. (B) Consensus matrix heatmap defining three clusters (k = 3) and their correlation area. (C) PCA analysis shows a remarkable difference in transcriptomes among the three patterns. (D) Kaplan–Meier curves of the overall survival in the TCGA-STAD and GSE84437 cohorts. (E) Heat map showing differences in clinicopathologic features and expression levels of MRCCGs between the three distinct patterns. STAD, stomach adenocarcinoma; MRCCGs, mitochondrial respiratory chain complexes genes; PCA, principal components analysis